Riken Corporation

Mitsuko Hara

Soichi Kojima

Takehisa Matsumoto

Daisuke Takaya

An object is to provide a compound capable of inhibiting activation of TGF-&#x3b2; receptors due to HCV, and a screening method for the compound. It has been found that a HCV-derived NS3 protease binds to type I TGF-&#x3b2; receptor, and this binding results in activation of TGF-&#x3b2; receptors. Moreover, binding sites between the NS3 protease and type I TGF-&#x3b2; receptor were identified, and it has been found that antibodies recognizing these binding sites inhibit activation of TGF-&#x3b2; receptors due to NS3 protease. Furthermore, it has been also found that screening for a compound capable of inhibiting activation of TGF-&#x3b2; receptors can be performed by using the inhibition of the binding between NS3 protease and type I TGF-&#x3b2; receptor or the like as an index.

Compounds having activity of suppressing activation of TGF-&#x3b2; receptor, method for screening of the compounds, and composition for preventing or treating disease caused by hepatitis C virus

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Wako, Japan

Mitsuko Hara