Wakamoto Pharmaceutical Co., Ltd.

Mitsuji Agata

Makoto Maeda

Masayoshi Goto

Shohei Sawaki

Yasuhiro Ootake

Yoshihiro Horio

Hatsunori Toyofuku

Sinji Inukai

Kenji Naito

Daisuke Morizono

Ryoki Takahashi

Manami Umezawa

The tetrazolylphenyl pivalate of the the following general formula or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 and R.sup.2 each represents a hydrogen atom, a lower alkyl group or other substituents; an elastase-inhibitory composition, a composition for preventing and treating emphysema and a composition for preventing and treating endotoxin-induced lung disorders each comprising the foregoing tetrazolylphenyl pivalate derivative or a non-toxic or acid-addition salt thereof.

Tetrazolylphenyl pivalate derivatives and medicinal composition

A tetrazoleacetic acid derivative represented by the following general formula I: ##STR1## wherein in the formula I, R represents a hydrogen atom or a lower alkyl group; A is an alkylene group having 2 to 5 carbon atoms; Ar is selected from the group consisting of a phenyl group, a naphthyl group, a furyl group, a thienyl group, a benzofuryl group, and a benzothienyl group; wherein the Ar may be substituted with a lower alkyl group, a lower alkoxy group, a halogen atom, a lower haloalkyl group, an alkylthio group and an alkylsulfonylamino group shows excellent aldose reductase inhibitory activity, and is quite effective as an essential component of a preventive medicine and/or remedy for diabetic complications.

Tetrazoleacetic acid derivatives and method of aldose reductase

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Kanagawa, Japan

Mitsuji Agata