Takeda Pharmaceutical Company Limited

Takeda Chemical Industries, Inc.

Mitsuhisa Yamano

Mitsutaka Goto

Masatoshi Yamada

Shinji Kawaguchi

Toshiaki Nagata

Jun-ichi Kawakami

Hideki Saitoh

Yasuaki Abe

Chitoshi Hatanaka

Yukio Mizuno

Yasuhiro Sawai

Sayuri Hirano

Masahiro Mizuno

Yoshiharu Maeda

Jun-Ichi Kawakami

Akira Nakatani

Hirotsugu Usutani

Takahiro Konishi

Ryoji Tsuruoka

The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (&#x3b3;-PGA-PAE) of poly(&#x3b3;-glutamic acid) (&#x3b3;-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.

Production method for poly(amino acid)

The present invention provides a method of efficiently producing an optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo -1,2,3,4-tetrahydropyrimidine derivative. The optically active piperidine-3-carboxamide or a derivative thereof, which is obtained by subjecting 1,4,5,6-tetrahydropyridine -3-carboxamide or a derivative thereof to an asymmetric reduction in the presence of a catalyst, is used as an intermediate.

Process for producing heterocyclic compound

[Problem] Provision of a superior rhodium catalyst and a production method of amine compound. [Solving Means] A rhodium complex coordinated with a compound represented by the formula 

Rhodium catalyst and method for producing amine compound

The present invention provides a novel ligand represented by the following formula and a novel transition metal complex having the ligand, which shows superior enantioselectivity and catalytic efficiency, particularly high catalyst activity, in various asymmetric synthesis reactions. A transition metal complex having, as a ligand, a compound represented by the formula wherein Ris a hydrogen atom or a Calkyl group optionally having substituent(s), and Rand Rare each a Calkyl group optionally having substituent(s), or the formula is a group represented by the formula wherein ring B is a 3- to 8-membered ring optionally having substituent(s).

Diphosphine ligand and transition metal complex using the same

Provided is a production method of an optically active dihydrobenzofuran derivative. A production method of an optically active form of a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof and the like. 

Production method of optically active dihydrobenzofuran derivative

Disclosed is a vinamidinium salt represented by the formula (I): [wherein Rrepresents a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or the like; Rand Rare the same or different and each represents a lower alkyl group, or alternatively Rand Rmay combine together to form a ring; Rand Rare the same or different and each represents a lower alkyl group, or alternatively Rand Rmay combine together to form a ring; X and Y are the same or different and each represents a bromine atom or a chlorine atom; n represents a number of not less than 2; and m represents 0 or n], and methods for synthesizing a heterocyclic ring compound using the salt.

Stable vinamidinium salt and nitrogen-containing heterocyclic ring synthesis using the same

A production method of a compound represented by the formula wherein R, R, R, R, R, R, R, R, R, R, Rand Rare the same or different and each is a hydrogen atom and the like, and R, R, R, R, R, R, Rand Rare the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.

Process for preparation of diphosphine compounds and intermediates for the process

A process for the production of phosphine-borane complexes represented by the general formula: or salts thereof: [wherein R, Rand Rare each independently a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heterocyclic group (with the proviso that Rand Rtogether with the adjacent phosphorus atom may form a 4- to 6-membered ring)], characterized by converting a compound represented by the general formula: in a solvent in the presence of a borane reagent: [wherein each symbol is as defined above].

Process for production of phosphine-borane complexes

A transition metal complex having 2,2'-bis[bis(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-1,1&#x2032;-binaphthyl as a ligand. The presence of the transition metal complex in the reaction system of an asymmetric reaction system allows the preparation of an objective compound having an objective absolute configuration with improved efficiency.

Transition metal complex having diphosphine compound as ligand

Method for producing peptides and their salts which have an agonist activity of luteinizing hormone releasing hormones secreted from the hypothalamus

Crystals of 7.beta.-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetamido]-3- (1-imidazo[1,2-b]pyridazinium)methyl-3-cephem-4-carboxylate hydrochloride or a solvate thereof, which are stable and improved in solubility in water, are useable for an excellent antibacterial agent.

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Osaka, Japan

Mitsuhisa Yamano