Shionogi Company Limited

Mitsuhiro Yonehara

Koji Masuda

Manabu Katou

Masanao Inagaki

Naoki Yoshikawa

Shiro Kida

Eiichi Kojima

Hiroyuki Tobinaga

Terukazu Kato

Manami Masuda

Mado Nakajima

Satoshi Kasuya

Novel compounds having D3 receptor antagonistic activity are provided. A compound represented by formula (I): 

Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect

A compound represented by the formula: or its pharmaceutically acceptable salt. Ring A is aromatic carbocycle or aromatic heterocycle, Z is &#x2014;O&#x2014; or &#x2014;S&#x2014;, Ris hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like, Rand Rare each independently hydrogen, halogen, hydroxy or the like, Ris a group represented by the formula: &#x2014;(CRR)&#x2014;R, Rand Rare each independently hydrogen, halogen, hydroxy or the like, n is an integer of 0 to 3, Ris carboxy, cyano, substituted or unsubstituted alkyl or the like, Ris halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like, and m is an integer of 0 to 3.

Oxadiazole derivative having endothelial lipase inhibitory activity

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Osaka, Japan

Mitsuhiro Yonehara