Hitachi Software Engineering Company, Ltd.

Mitsuhiro Tachibana

Keiichi Sato

Motonao Nakao

Toshiki Morita

Naoki Yokokawa

Seiichiro Ito

Kenji Yamamoto

Toshiaki Tanaka

Hiroshi Kishida

Katsuya Mizuno

Shigeru Kijima

Provided is an apparatus for detecting biopolymers (DNA) capable of total analysis including non-reacted samples without complicated operations such as washing. A DNA probe is fixed to one of electrodes and direct current voltage is placed between the electrodes, so that it becomes possible to separate complementary strand sample DNA and non-complementary strand sample DNA. By analyzing from a ratio in the whole reaction system, it is possible to obtain clearer results. Further, by using electrophoresis by gel together, it is possible to separate reacted samples and non-reacted samples to perform measurements therefor in the same reaction field.

Apparatus for detecting biopolymers and cartridge

A spotting pin capable of spotting equal amounts of a solution in a sequential manner comprises a first member having a solution holding portion formed at the tip thereof for holding a predetermined amount of solution, and a second member having a solution supply portion for holding the solution by a capillary action, the second member adapted to slide along the first member. As the solution supply portion is brought into contact with the solution holding portion , the solution enters the solution holding portion from the solution supply portion by a capillary action. As the solution supply portion and the solution holding portion are separated from each other, a predetermined amount of the solution can be carried in the solution holding portion . Then, as the solution holding portion is brought into contact with a water-absorbing support , a spot of a predetermined amount of the solution can be formed thereon.

Spotting pin

Hybridization reaction apparatus and hybridization method

The present invention provides a high-sensitive, inexpensive biochip reader for reading a biochip as compared to a fluorescence method. The biochip reader is provided with an X-Y stage ( ) for mounting a biochip ( ) and scanning the biochip ( ) in a two-dimensional manner, a controller ( ) for the X-Y stage, a magnetic sensor ( ) for reading the magnetic field strength, an ohmmeter ( ), and a computer ( ) for signal processing. As a result, a high-performance, inexpensive biochip reader can be provided without using an expensive laser or an expensive optical system, by employing a magnetic sensor and a disk driving mechanism generally used in a hard disk drive and the like.

Biochip reader and labeling reagent

The present invention enables the accurate management of the total number of spotting counts for each spotting pin. An IC chip is installed on the spotting pin to allow the IC chip to accumulate spotting-count information, and during each spotting time the information is loaded up and displayed.

Spotting pin, spotting device and method for spotting biomolecules

Identically shaped spots can be formed sequentially and stably by a spotting pin comprising a bar-like plunger . Four projections each formed in the shape of a top portion of a quadrangular pyramid are formed on the head of the plunger . The apexes of the quadrangular pyramids constituting the projections are located inside a virtual plane extending from the peripheral wall of the plunger.

Method and apparatus for reading fluorescence

Disclosed is a biopolymer (DNA) detector capable of performing overall analysis including an unreacted sample without needing any complex work such as washing or the like. A DNA probe is fixed to an electrode plate and the electrode plate is displaced by applying a DC voltage between electrode plates and Thus, sample DNA to be detected can be separated. It becomes possible to obtain a clearer result by performing analysis based on a ratio of an entire reaction system.

Growing community of inventors

Kanagawa, Japan

Mitsuhiro Tachibana