Teikoku Seiyaku Co., Ltd.

Kagawa University

Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo

Fushimi Pharmaceutical Company, Limited

Fujifilm Toyama Chemical Co., Ltd.

Matsutani Chemical Industry Co., Ltd.

National University Corporation Kagawa Univesity

Mitsuhiro Nagata

Ken Izumori

Keiji Tsusaki

Masaaki Tokuda

Masaaki Ueki

Yutaka Ishida

Koji Murao

Mohammad Akram Hossain

Takeo Takahashi

Tomohiko Taminato

Kazuyuki Hirooka

Terukazu Tanaka

Fuminori Yamaguchi

Gan Muneuchi

Taizo Tasaka

Toshihiko Ishida

Osamu Miyamoto

Toshifumi Itano

Hiroyuki Inaba

Katsumi Ihara

Sayoko Inazuki

Mohammed Akram Hossain

Asahiko Taminato

A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.

Method of utilizing physiological activity of rare saccharide and composition containing rare saccharide

To control neuropathic pain produced by various mechanisms. Disclosed is a composition for elimination, relief or reduction of neuropathic pain comprising, as an active ingredient, at least one substance selected from the group consisting of D-allose, a derivative of D-allose, D-psicose and a derivative of D-psicose preferably in an amount of 0.01 to 90% by weight. The composition may comprise a mixture of D-allose and/or a derivative thereof and D-psicose and/or a derivative thereof at a ratio of 1:1 to 10:1. The neuropathic pain may be one induced by a disease selected from the group consisting of trigeminal neuralgia, postoperative pain, periodontitis, gingivitis, gingivostomatitis, oral ulcer, herpes zoster, postherpetic neuralgia, diabetic neuritis, causalgia, phantom limb pain and malignant tumor. Also disclosed is use of the composition for elimination, relief or reduction of neuropathic pain by administering the composition to a patient with neuropathic pain in such an amount that 0.01 to 100 g of the at least one substance can be taken by the patient per day.

Utilization of anti-neuropathic pain effect of D-allose and D-psicose

To provide a patch containing fentanyl for mucous membrane of the oral cavity (oral transmucosal fentanyl), which rapidly increases the serum concentration of the drug, is easy in handling and is superior in safety. The patch can be prepared by laminating on one side of a drug layer which contains fentanyl or its salt as an active ingredient, methyl vinyl ether-maleic anhydride copolymer as an adhesive, and at least one substance selected from the group consisting of hydroxypropylcellulose, hydroxypropylmethylcellulose and hydroxyethylcellulose as a thickener, a support layer hardly soluble or insoluble in water, and a backing in this order.

Patch containing fentanyl for mucous membrane of oral cavity

Growing community of inventors

Takamatsu, Japan

Mitsuhiro Nagata