Sumitomo Chemical Company, Limited

J.s.t.mfg. Co.,ltd.

Sumitomo Dainippon Pharma Co., Ltd.

Mitsuhiro Matsumoto

Yuji Funaki

Shoichi Sasaki

Koji Shiota

Yuichi Tonai

Toshihiro Terashima

Masunori Kajikawa

Koichi Kino

Masahito Sugiura

Toshihiro Kai

Emi Shimizu

The present invention provides an agent for the prophylaxis or therapy of autoimmune diseases or allergic diseases, which contains an anti-Embigin antibody, particularly an anti-Embigin antibody showing cytotoxicity or a cytotoxicity inducing activity, an agent for the prophylaxis or therapy of diseases involving Th17 cell, and a cytotoxic agent to Th17 cell. In addition, an agent for detection of Th17 cell, which contains an anti-Embigin antibody, a convenient detection method of Th17 cell, which uses the agent, a method of efficiently delivering a drug and the like in a Th17 cell selective manner, which uses an anti-Embigin antibody, and a drug delivery system to Th17 cell are provided.

Treatment drug for autoimmune diseases and allergic diseases

A base connector includes an insulating base housing and a plurality of base contacts retained by the base housing. An anterior wall of the base housing includes a central convex portion which is formed at the center portion in a left-and-right direction of the anterior face of the anterior wall and projects forward, and a pair of concave portions formed on both sides sandwiching the central convex portion therebetween. At least a part of the upper face on the anterior wall including the upper face of the central convex portion is formed as a flat face. The upper face of the anterior wall is provided with a wide portion including the upper face of the central convex portion and being relatively wide in the front-and-rear direction, and a pair of narrow portions relatively narrow in the front-and-rear direction corresponding in position to the pair of concave portions. The wide portion is provided with a flat adsorbed face, which can be adsorbed by an adsorption member.

Base connector, socket connector and complex type connector

To provide a floating connector wherein strengths against pull-out forces in the height direction are high and both housings are resistant to separation, the slide housing slides in any direction perpendicular to the height direction to reliably absorb the deviation in the position of the floating connector in relation to that of the counterpart connector without resulting in any defective contact with the counterpart contacts nor buckling of the contacts, the floating connector can be produced easily, and the floating connector has a high self-supportability through setting an appropriate rigidity of the contacts. It is a floating connector wherein the connecting parts of the contacts are pressed into the base housing, the contacting parts of the contacts are pressed into the slide housing, and both housings are so related to each other by means of protruding parts protruding in the width direction and grooves into which the protruding parts are inserted that both housings can slide in any directions perpendicular to the height direction.

Floating connector

There is disclosed an imine compound of the general formula: ##STR1## wherein and R.sup.1 and R.sup.2 are, the same or different, each a C.sub.1 -C.sub.5 alkyl group, or R.sup.1 and R.sup.2 are combined together to form a C.sub.4 -C.sub.5 alkylene group; R.sup.3 is a C.sub.1 -C.sub.5 alkyl group, a C.sub.3 -C.sub.4 alkenyl group or a C.sub.3 -C.sub.4 alkynyl group, which is useful as an intermediate for production of agrochemicals and the like. Also disclosed are an amide compound useful as a raw material of the imine compound and production processes for these compounds.

Imine compounds and their production

There is disclosed an imine compound of the general formula: ##STR1## wherein R.sup.1 and R.sup.2 are, the same or different, each a C.sub.1 -C.sub.5 alkyl group, or R.sup.1 and R.sup.2 are combined together to form a C.sub.4 -C.sub.5 alkylene group; R.sup.3 is a C.sub.1 -C.sub.5 alkyl group, a C.sub.3 -C.sub.4 alkenyl group or a C.sub.3 -C.sub.4 alkynyl group, which is useful as an intermediate for production of agrochemicals and the like. Also disclosed are an amide compound useful as a raw material of the imine compound and production processes for these compounds.

Growing community of inventors

Osaka, Japan

Mitsuhiro Matsumoto