Ajinomoto Co., Ltd.

Tokyo Institute of Technology

Mitsuhiro Kishino

Hideo Hosono

Hiroyuki Kojima

Toshiharu Yokoyama

Michikazu Hara

Masaaki Kitano

Kazuteru Yamada

Hiromi Noguchi

Toru Numaguchi

Munenobu Ito

Mitsuyoshi Seki

Koji Igarashi

Toshimichi Kamei

Tomoharu Takenouchi

Takahiko Kureyama

Provided is a novel production system that does not involve, or can minimize, the transport of liquid ammonia in the production of an organic compound or the production of a microorganism by microbial fermentation. A production system for an organic compound or a microorganism includes: an ammonia synthesis apparatus in which an ammonia-containing gas is synthesized by reaction of a source gas containing hydrogen and nitrogen in the presence of a supported ruthenium catalyst; and a culture apparatus that cultures a microorganism having organic compound productivity using ammonia originating from the ammonia-containing gas obtained by using the ammonia synthesis apparatus.

Production system and method of production for organic compound or microorganism

A production system for a product selected from a nitrogen-containing product and a fermented and cultured product that does not involve (or can minimize) the transport of liquid ammonia can include: an ammonia synthesis apparatus in which an ammonia-containing gas is synthesized by reaction of a source gas containing hydrogen and nitrogen in the presence of a supported metal catalyst containing as a support one or more selected from the group consisting of: i) a conductive mayenite compound; ii) a two-dimensional electride compound or a precursor thereof; and iii) a complex formed of a support base containing at least one metal oxide selected from ZrO, TiO, CeO, and MgO and a metal amide represented by a formula M(NH)(where M represents one or more selected from Li, Na, K, Be, Mg, Ca, Sr, Ba, and Eu; and x represents a valence number of M) supported by the support base.

Production system and method of production for product selected from nitrogen-containing product and fermented and cultured product

The present invention provides a method for separating and obtaining a basic amino acid hydrochloride from a basic amino acid fermentation broth or an enzyme reaction solution which enzyme reaction is catalyzed by viable microbial cells which are able to produce a basic amino acid, each containing sulfate ions, wherein product yields and qualities are almost the same and are secured more easily, as compared with the conventional technique. The method may include the steps of adding a metal chloride such as calcium chloride, potassium chloride, magnesium chloride, and barium chloride to the basic amino acid fermentation broth or the enzyme reaction solution containing sulfate ions to precipitate the sulfate ions as crystals of the resulting metal sulfate, (2) removing the metal sulfate crystals from the basic amino acid solution, (3) cooling the basic amino acid fermentation broth or the enzyme reaction solution from which the metal sulfate crystals have been removed while maintaining the concentration of the metal sulfate below its saturation concentration, resulting in precipitatation the basic amino acid as hydrochloride crystals, and (4) separating and collecting the basic amino acid hydrochloride crystals.

Methods for obtaining crystals of a basic amino acid hydrochloride

A method of producing L-phenylalanine employing a microorganism in which cultivation of the microorganism is continued while precipitating alpha-crystals of L-phenylalanine in the culture by means of seed crystals or a pH shift.

Method of producing alpha crystals of L-phenylalanine

Growing community of inventors

Kanagawa, Japan

Mitsuhiro Kishino