Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Eisai Research Institute

Mitsuhiro Ino

Shigeki Hibi

Yoshinori Takahashi

Hisashi Shibata

Yorihisa Hoshino

Kogyoku Shin

Koichi Kikuchi

Motohiro Soejima

Tatsuya Yoshiuchi

Mutsuko Ono

Tetsuya Hirakawa

Masae Fujisawa

Kouichi Kikuchi

Takayuki Hida

Kohei Sawada

Norimasa Miyamoto

Isao Tanaka

Takashi Yoshinaga

Mutsuko Tabata

Toru Oki

Shinji Hatakeyama

Tetsuhiro Niidome

Yukio Nishizawa

Eiki Takahashi

The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein Rdenotes a hydrogen atom, a Calkyl group, a Calkoxy group and the like; Rdenotes a halogen atom, a cyano group, a nitro group, a Calkyl group, a Calkenyl group, Calkynyl group and the like; Rdenotes a Caromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR(wherein Rdenotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated Calkyl group and the like) and, in this case, at least two of X, Y and Z denote CR.

Imidazo[1,2-b]pyridazine compound

Compounds represented by the general formula: [wherein Rrepresents methoxy, ethyl, methylthio, etc., R, Rand Reach represent hydrogen, a halogen, etc., Rand Reach represent &#x2014;X&#x2014;X&#x2014;X(wherein Xrepresents a single bond or &#x2014;CO&#x2014;, Xrepresents a single bond, &#x2014;NR, etc. and Xand Reach represent hydrogen, Calkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.

Pyrazolo[1,5-a]pyridines and medicines containing the same

A compound represented by the formula: [wherein Ris methoxy, methylthio, ethyl, etc.; Rand Rare each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R, Rand Rare Calkoxy while the remaining one is methoxymethyl, etc.], a salt thereof, or a hydrate of the foregoing. This compound has excellent antagonism against corticotropin-releasing factor receptor.

7-phenylpyrazolopyridine compounds

Pyrazolo[1,5-a] pyridines and medicines containing the same

A non-human animal in which a gene coding for the N-type calcium channel is disrupted to lack functional N-type calcium channel, and a method for screening for a substance having a pharmacological action on blood pressure control, transmission of pain, blood sugar level control and so forth by using the animal.

N-calcium channel knockout animal

The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof,wherein Ris a hydrogen atom, etc.; Ris a hydrogen atom, etc.; M' represents a hydrogen atom, a halogen atom or a Calkyl group; R&#x2032; represents a hydrogen atom or a Calkyl group; and W&#x2032; represents a phenyl group, pyridyl group, thienyl group, or furyl group, each being optionally substituted; and a pharmacologically acceptable salt thereof or hydrates thereof.

Tricyclic fused heterocyclic compound, process for preparing it and medicament comprising it

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Ushiku, Japan

Mitsuhiro Ino