Juridical Foundation, Japanese Foundation for Cancer Research

Otsuka Pharmaceutical Company, Limited

Japanese Foundation for Cancer Research

Kyowa Hakko Kogyo Co., Ltd.

Mitsuaki Yoshida

Haruo Sugano

Fumio Shimizu

Kenichi Imagawa

Susumu Sekine

Seiga Itoh

Tadatsugu Taniguchi

An antibody of a human leukemia virus-related peptide obtained by collecting an antibody produced in a mammal body by administering to the mammal an antigen prepared by reacting a human leukemia virus-related peptide selected from the group consisting of:

Antibodies to human leukemia virus-related peptides and a process for

Recombinant plasmids are constructed by inserting a DNA fragment coding for a fused protein of an adult T cell leukemia virus antigen peptide and an enzyme into a vector DNA. Microorganisms are transformed with the recombinant plasmid and thereafter cultured to express the fused protein. The fused protein is useful for the detection and diagnosis of adult T cell leukemia.

Derivative of adult T cell leukemia virus antigen peptide

A viral genomic DNA and fragments thereof which are complementary to genomic RNA of human leukemia virus and a recombinant DNA molecules containing the genomic DNA or fragments thereof. The genomic DNA and fragments thereof and the recombinant DNA molecules are useful for the diagnosis, prevention and therapy of human leukemia.

DNA complementary to RNA of human leukemia virus

Recombinant plasmids are constructed by inserting a DNA fragment containing the env gene of adult T cell leukemia virus or a part thereof into a vector DNA. Microorganisms are transformed with the recombinant plasmid and thereafter cultured to express the peptide. The antigen polypeptide encoded by the env gene is useful for the detection and diagnosis of adult T cell leukemia.

Adult T cell leukemia virus antigen polypeptide

Human leukemia virus-related peptides, antibodies of the peptides and a

Growing community of inventors

Tokyo, Japan

Mitsuaki Yoshida