Astellas Pharma Gmbh

Mitsuaki Okumura

Makoto Inoue

Ryo Sato

Yoshito Abe

Kazuhiko Ohne

Yuki Sawada

Kozo Sawada

Tsuyoshi Mizutani

Kenichiro Imamura

Kentaro Sato

Masahiko Hayakawa

Takeyuki Nagashima

Akira Kanai

Eiji Kawaminami

Kenichi Kawaguchi

Hisao Hamaguchi

Sunao Imada

Takahiro Nigawara

Yohei Seki

Ikumi Kuriwaki

Kazuyuki Kuramoto

Tomoyoshi Imaizumi

Hiroki Fukudome

Hideyuki Watanabe

Kohei Inamura

Hiroki Ishioka

Nobuaki Amino

Keisuke Maki

Yoshiyuki Kido

Tomohiro Yoshinari

[Problem] To provide a compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer. [Means for resolution] The present inventors have studied about a compound that is useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer and have found that a quinazoline compound has an excellent degradation-inducing action on a G12D mutant KRAS protein and a G12D mutant KRAS inhibition activity and can be used as a therapeutic agent for pancreatic cancer, thus completing the present invention. The quinazoline compound or a salt thereof of the present invention can be used as a therapeutic agent for pancreatic cancer.

Quinazoline compound for inducing degradation of G12D mutant KRAS protein

Phenylacetamide compounds of the formula having sulfonyl group and cycloalkyl group on the phenyl group and having heteroaryl group on the nitrogen atom in the amide have an excellent glucokinase activation action.

Substituted pyrazine compounds

The invention relates to compound of the formula (I) or its salt, in which R, R, Rand Rare as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-&#x3b1; mediated diseases. 

Pyrazolopyridine derivatives

The invention relates to compound of the formula (I) or its salt, in which R, R, Rand Rare as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-&#x3b1; mediated diseases 

Pyrrolopyridazine derivatives

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Tokyo, Japan

Mitsuaki Okumura