Maruko Seiyaku Co., Ltd.

Taiho Pharmaceutical Company Limited

Mitsuaki Nagasaka

Sachio Ohno

Kiyoshi Mizukoshi

Mikio Hori

Kazuo Kato

Yoshiki Nakamura

Motoaki Tanaka

Hajime Fujimura

Hidekazu Miyake

Osamu Komatsu

Hajimu Yamamoto

Shigeo Senda

Khosuke Fujiwara

Osamu Ohtani

Eiichi Katho

Kihachiro Izumi

Yuko Ebihara

Osamu Ootani

Kenji Ichihara

Takao Ban

Tadashi Kitamikado

Kiyoshi Kato

Novel ergoline derivatives and acid addition salts thereof are disclosed. These ergoline derivatives possess excellent anti-hypertensive activity, vasodilating activity, anti-ulcer activity, gastric secretion inhibitory activity, brain metabolism improving activity, anti-depressive activity and dopamine-like activity, and, therefore, are useful for prevention and treatment of various diseases such as hypertension, a wide variety of vein disorders, peptic ulcer, brain absormality, depression, Parkinson's disease, high prolactin blood disease, etc.

Ergoline derivatives and acid addition salts thereof

Novel pyridine compounds and the pharmaceutically acceptable salts thereof having a specific inhibitory activity on thromboxane A.sub.2 biosynthesis in mammals useful for prevention and treatment of various disorders caused by thromboxane A.sub.2, for example, thrombosis, cardiac infarction, diabetic vascular complications, asthma, etc. are disclosed.

Certain pyridyloxy-or-thio-phenyl propenoic acid derivatives

Novel 1(2H)-isoquinolone compounds and the acid addition salts thereof are disclosed. These compounds are useful as pharmaceutical agents in view of their anti-ulcer, stomach mucous membrane blood flow increasing, anti-hypertensive, analgesic, anti-histamine, anti-cholinergic and gastric secretion inhibitory activities.

1(2H)-Isoquinolone compounds and acid addition salts thereof

A flavan compound represented by the formula (I) ##STR1## wherein R, R.sub.1, R.sub.2 and R.sub.3 are as defined above, and the pharmaceutically acceptable acid addition salt thereof, which are useful as pharmaceutical agent having anti-convulsive, anti-ulcer, anti-arrythmic and diuretic activities.

Flavan compounds and acid addition salts thereof

Cis or trans-1,5-benzothiazepine compounds represented by the formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and R.sub.2 represents a hydrogen atom, an alkyl group or a hydroxyalkyl group and the pharmaceutically acceptable acid addition salts and quaternary ammonium salts thereof which exhibit anticholinergic activity and are useful as anti-ulcer, gastric secretion inhibiting and antispasmodic agents in mammals, and a process for preparing the same.

1,5-Benzothiazepine compounds

Pyrazole derivatives represented by the formula ##SPC1## Wherein R, X, R.sub.2 and R.sub.3 are hereinafter defined, which are useful as analgesics and anti-inflammatory agents and a process for preparing the pyrazole derivatives are disclosed.

Pyrazole derivatives and process for preparing the same

Growing community of inventors

Aichi, Japan

Mitsuaki Nagasaka