Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Mitsuaki Miyamoto

Kazuo Okano

Shinya Abe

Isao Yamatsu

Hiroyuki Yoshimura

Koukichi Harada

Tetsuya Kawahara

Shigeru Souda

Yoshimasa Machida

Shuhei Miyazawa

Osamu Asano

Kouichi Katayama

Naoyuki Shimomura

Takeshi Suzuki

Kenji Hayashi

Kozo Akasaka

Hironori Ikuta

Richard S Clark

Kouji Nakamoto

Youji Yamagishi

Satoshi Katayama

Tohru Fujimori

Kouji Yamada

Kenzo Muramoto

Hiroshi Obaishi

Hajime Tsunoda

Yoshimori Sakuma

Yoshinori Sakuma

Tsutomu Kawata

Motohiro Soejima

Tatsuya Yoshiuchi

Junsaku Nagaoka

Masayuki Tanaka

Koji Yamada

Tsutomu Yoshimura

Katsuhiro Moriya

Hiromasa Suzuki

Keizo Sato

Seiichi Kobayashi

Makoto Okita

Makoto Kaino

Shuichi Suzuki

Kokichi Harada

Koichi Katayama

Yukio Nishizawa

Fumihiro Ozaki

Nobuaki Sato

Akiharu Kajiwara

Ieharu Hishinuma

Hiroshi Tanaka

Masanobu Shinoda

Fumiyoshi Matsuura

Itaru Tsukada

Atsushi Kamada

Makoto Kotake

Taro Terauchi

Toshiyuki Matsuoka

Yoshimitsu Naoe

Akifumi Kimura

Osamu Ito

Motoji Kogushi

Hiroko Kobayashi

Ken-ichi Chiba

Naoto Ono

Syuhei Miyazawa

Yoshiaki Oohashi

Takashi Sato

Koichi Kikuchi

Naoki Yoneda

Ichiro Yoshida

Yasutaka Takase

Junichi Kamata

Hiromitsu Yokohama

Yoshiaki Ohashi

Takashi Musha

Manabu Shirato

Shigeru Akasofu

Hidenori Seshimo

Richar S Clark

Takashi Musya

Naoyuki Kimomura

Tsutomu Kawada

Futoshi Miyazaki

Daiya Shimokubo

Ken-Ichi Chiba

Keni-Ichi Chiba

Takashii Musha

A 2-iminoimidazole derivative represented by the formula: {wherein R, Rand Rrepresent hydrogen, optionally substituted Calkyl, etc.; Rrepresents hydrogen, Calkyl, Calkyloxycarbonyl, etc.; Yrepresents a single bond, &#x2014;CH&#x2014;, etc.; Yrepresents a single bond, &#x2014;CO&#x2014;, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R&#x2013;Rrepresent hydrogen, Calkyl, hydroxyl, Calkoxy, etc., and Rand Ror Rand Rmay bond together to form a 5- to 8-membered heterocycle], etc.}or salt thereof.

2-iminoimidazole derivatives (2)

A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R&#x2013;Rrepresent hydrogen, halogen, Calkyl, etc.; Rrepresents hydrogen, Calkyl, Calkoxy-Calkyl, etc.; Rrepresents hydrogen, Calkyl, Calkyloxycarbonyl, etc.; Yrepresents a single bond, &#x2014;CH&#x2014;, etc.; Yrepresents a single bond, &#x2014;CO&#x2014;, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R&#x2014;Rrepresent hydrogen, Calkyl, hydroxyl, Calkoxy, etc.; and Rand Ror Rand Rmay bond together to form a 5- to 8-membered heterocyclic ring], etc.},or a salt thereof.

2-iminopyrrolidine derivatives

The present invention discloses compounds and compositions of formula (I): having inhibitory activity on activation of STAT6, wherein X represents quinoline, isoquinoline, quinazoline or imidazopyridine; Y represents phenyl, piperazine, pyridine, thiophene, thiazole, oxathiazole or oxathiadiazole; and variables Z, n, R, R, Rand Rare as defined in the claims.

Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof

Nitrogen-containing tricyclic compounds and drugs containing the same

Heterocyclic-ring condensed benzothiazine compound

A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by formula (I)

A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are useful in the pharmaceutical field, especially in treating allergic diseases. ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.

1,4-diazepine derivative and its pharmaceutical use

A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. ##STR1##

Glycerin derivative and its pharmacological use

A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.

A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OOO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.

A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to treat allergic diseases: ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.

A triazolo-1,4-azepine compound of the below given formulas and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.

Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals

A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases, ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.

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Ibaraki, Japan

Mitsuaki Miyamoto