Kaneka Corporation

Tokyo University of Science Foundation

Mitsuaki Kitano

Noriyuki Kizaki

Kazunori Hosoe

Mikio Kitahara

Hideyuki Kishida

Tatsumasa Mae

Tomoyuki Nakaishi

Kaku Nakagawa

Misuzu Tsukagawa

Hiroshi Kita

Hiroshi Shimada

Masutoshi Nojiri

Minpei Kuroda

Yoshihiro Mimaki

Hirokazu Sakamoto

Tatsuya Moutai

Yutaka Sashida

Daisuke Kitamura

Yu Fu

Atsushi Sakamoto

Shoma Tanaka

Masanori Kato

Toshihide Fujii

Yoshiyuki Shinagawa

It is an object of the present invention to provide a method for efficiently producing a B cell population comprising B cells that recognize a specific antigen. According to the present invention, provided is a method for producing a B cell population, comprising: a step (c) of culturing a cell population comprising B cells together with a specific antigen in the absence of IL-21, in the absence of IL-4, and in the presence of a cytokine other than IL-21 and IL-4, while giving stimulation mediated by CD40 and a BAFF receptor to the cells; and a step (d) of culturing the cell population comprising B cells, while giving stimulation mediated by has to the cells, so as to obtain a B cell population comprising B cells that recognize the specific antigen.

Method for producing B cell population and method for producing monoclonal antibody using same

A method for producing a transgenic cell, may include contacting, in vitro, (i) a virus comprising: a chimeric protein of an antibody-binding protein and a vesicular stomatitis virus G (VSV-G) protein; and a foreign gene, with (ii) a target cell and an antibody specific to the target cell, and/or a target cell comprising a membrane antibody, to infect the target cell with the virus.

Method for producing transgenic cell

A method for cultivating a plant includes applying allantoin to a plant; exposing the plant to a temperature of about 30&#xb0; C. or more for at least about 60 minutes; and growing the plant in a cultivation medium.

Composition comprising allantoin and method of applying allantoin to a plant

A composition for preventing or ameliorating multiple risk factor syndrome involving visceral fat-type obesity, diabetes mellitus, hyperlipemia and hypertension, which comprises at least one member selected from the group consisting of a licorice hydrophobic extract, a turmeric extract, a clove extract, and a cinnamon extract.

Compositions for preventing or ameliorating multiple risk factor syndromes

The object of the present invention is to provide PPAR&#x3b3; ligand derived from naturally occurring sources and a composition for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity comprising the PPAR&#x3b3; ligand as an active agent. The present invention relates to a ligand for peroxisome proliferator-activated receptor The composition according to the present invention, which comprises the PPAR&#x3b3; ligand as an active agent is useful for preventing and/or improving Insulin Resistance Syndrome, diabetes mellitus, obesity or visceral fat obesity.

Ligand for peroxisome proliferator-activated receptor

Growing community of inventors

Hyogo, Japan

Mitsuaki Kitano