Ono Pharmaceutical Co., Ltd.

Ono Pharmaceuticals Co., Ltd.

Mitoshi Konno

Nobuyuki Hamanaka

Takahiko Nakae

Tadamitsu Kishimoto

Mikio Konishi

Masaki Hayashi

Nobuo Katsube

Takao Tokuhiro

Hiroyuki Itoh

Sadahiko Iguchi

Katsuhito Sakaki

Masao Naka

Katsumi Ohta

Takahiko Nakao

Hydroxamic acid derivatives, process for the production thereof and drug containing the same as the active ingredient

Fused thiophone derivatives and drugs containing the same as the active ingredient

The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, posses an antagonistic activity on leukotriene B.sub.4.

Phenylalkan(en)oic acid

The phenylalkan(en)oic acids of the formula: ##STR1## wherein the substituents are defined in the specification.

The phenylalkan(en)oic acids of the formula: ##STR1## as defined herein, possess an antagonistic activity on leukotriene B.sub.4.

The phenylalkan(en)oic acids of the formula: ##STR1## as defined in the specification, possess an antagonistic activity on leukotriene B.sub.4.

The phenylalkan(en)oic acids of the formula: ##STR1## wherein A is

A 2-aminomethyl phenol derivative of the formula (I): ##STR1## wherein X is a halogen atom; R.sup.1, R.sup.2, R.sup.3 and R.sup.4 which may be the same or different are each a hydrogen atom or a straight or branched chain alkyl group having 1 to 4 carbon atoms; n is 2, 3, 4 or 5 and a pharmaceutically acceptable acid addition salt thereof are disclosed. Also disclosed is a process for preparing such derivative or a pharmaceutically acceptable acid addition salt thereof.

2-Aminomethyl phenol derivative and process for preparing thereof

A 2-acyl-6-aminomethylphenol derivative having the formula (I): ##STR1## wherein R.sup.1 represents a straight chain or branched chain alkyl group of 1 to 6 carbon atoms unsubstituted or substituted with 1 to 3 halogen atoms; a hydrogen atom or a group having the formula (II):

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Osaka, Japan

Mitoshi Konno