Other

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Teva Pharmaceutical Industries Limited

Mitchell Shirvan

Meir Bialer

Jeff Sterling

Ruth Levy

Yaacov Herzig

Sasson Cohen

Alex Veinberg

David Lerner

John P Finberg

Moussa B Youdim

Moussa B H Youdim

John P M Finberg

Jacob Herzig

Salim Hadad

A method for the treatment or prevention of pain and/or a headache disorder using a derivative of a valproic acid amide or a 2-valproenic acid amide, as well as pharmaceutical compositions comprising these derivatives or compounds.

Use of derivatives of valproic acid amides and 2-valproenic acid amides for the treatment or prevention of pain and/or headache disorders

Use of derivatives of valproic acid and 2-valproenic acid amides for the treatment of mania in bipolar disorder

Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of mandelic acid. Parkinson's disease, dementia, epilepsy, convulsions, or seizures are treated by administering a compound of the formula:

Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives

Compositions containing and methods of using 1-aminoindan and

A compound having the structure: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are independently the same or different and are hydrogen, a C.sub.1 -C.sub.6 alkyl group, an aralkyl group, or an aryl group, and n is an integer which is greater than or equal to 0 and less than or equal to 3. Also provided are a compound containing a 2-valproenoic moiety, pharmaceutical compositions comprising these compounds, and methods of using them for the effective treatment of epilepsy and other neurological disorders.

Derivatives of valproic acid amides and 2-valproenoic acid amides,

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Jerusalem, Israel

Mitchell Shirvan