Sanford-burnham Medical Research Institute

The Burnham Institute

Burnham Institute for Medical Research

Mitchell Koolpe

Elena B Pasquale

Keith K Murai

Novel agents are described that bind to Eph receptors. Methods of using these agents to modulate the activity of Eph receptors, stimulate apoptosis, and deliver therapeutic agents are also described. Methods of screening for agents capable of selectively binding to Eph receptors are also described.

Agents that modulate Eph receptor activity

The application is related to the identification of peptides that selectively bind to Eph receptors of the B class. Also disclosed are uses of such peptides in the treatment of a variety of diseases. Additionally, imaging tumors in patients is described by administrating labeled peptides to patients and then obtaining an image of the labeled peptides.

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Palo Alto, CA, United States of America

Mitchell Koolpe