Archer Daniels Midland Company

Bristol-myers Squibb Compnay

Mitchell J Schultz

Thomas P Binder

John Glenn Soper

William Chris Hoffman

Naveen Sudharsan

Pam Anklam

Stephen J Howard

Alexandra Sanborn

Kenneth Stensrud

Joseph F Payack

Padmesh Venkitasubramanian

Ahmad K Hilaly

Chung-Pin H Chen

Jonathan Clive Tripp

Wendel William Doubleday

Richard J Fox

Dayne Dustan Fanfair

Sabrina E Ivy

Saravanababu Murugesan

Kris N Mani

John G Soper

Joseph Francis Payack

A method is provided for separating a dicarboxylic acid product from a mixture containing such dicarboxylic acids. The method involves: providing a dicarboxylic acid-containing mixture of which at least 35% of the carboxylic acid content of the mixture is a dicarboxylic acid product of interest; running an extraction of said dicarboxylic acid-containing mixture through a chromatographic column configured with an amphoteric resin, such that the dicarboxylic acid product elutes preferentially from the dicarboxylic acid-containing mixture. In certain embodiments, the dicarboxylic acid product of interest can be a glucaric or gluconic acid product from a mixture of either or both of these with still other carboxylic acids.

Process for separation and purification of a dicarboxylic acid containing mixture

A process is provided for making esters of FDCA, in which an aqueous feed comprising glucaric acid is first reacted with a high boiling first alcohol in the presence of an acid catalyst and with removing water during the reaction, to form a first product mixture comprising a first ester of FDCA and the high boiling first alcohol, then unreacted high boiling first alcohol is removed from the first product mixture. The first ester of FDCA and the high boiling first alcohol is then transesterified with a lower boiling second alcohol selected from the group consisting of methanol, ethanol, isopropanol and n-propanol, to form a second product mixture comprising a second ester of FDCA with the lower boiling second alcohol, and the second ester of FDCA with the lower boiling second alcohol is recovered.

Process for making esters of 2,5-furandicarboxylic acid

Described herein is a method of adjusting the composition of a chromatography product to achieve a target enriched proportion of a desired component from an input feed having a lower proportion of the desired component using simulated moving bed ('SMB') chromatography wherein the eluent for the SMB apparatus may comprise the very input feed being enriched. The method is exemplified by enriching a high fructose corn syrup from a 42% fructose syrup to a 55% fructose syrup without substantially reducing the dissolved solids concentration of the 55% syrup relative to the input 42% syrup. The 42% syrup is also used as the eluent for the SMB apparatus and may be reconstituted from the raffinate stream by passing the raffinate stream over a glucose isomerase column alone or in combination with a dextrose feed. The method reduces water usage and saves energy by minimizing the need for evaporation to obtain a 55% fructose syrup with a high dissolved solids content.

Method for adjusting the composition of chromatography products

A process is described for making acrylic acid from dextrose, which comprises fermenting dextrose; removing solids from the resulting fermentation broth; removing lactic acid from the clarified broth by extraction into an organic solvent; separating out the lactic acid-loaded organic solvent while recycling at least a portion of the remainder back to the fermentation step; reacting the lactic acid with ammonia to provide a dehydration feed comprising ammonium lactate while preferably recycling the organic solvent; carrying out a vapor phase dehydration of the ammonium lactate to produce a crude acrylic acid product; and purifying the crude acrylic acid by distillation followed by melt crystallization, chromatography or both melt crystallization and chromatography.

Process for making acrylic acid from dextrose

A process is provided for chromatographically separating propionic acid from acrylic acid. By means of the inventive process, a reduced propionic acid content acrylic acid product is enabled having a propionic acid content comparable to acrylic acid products from the conventional two stage oxidation of propylene, but wherein the acrylic acid has been produced with a higher propionic acid content by alternative methods.

Separation of propionic acid from acrylic acid

A process for making esters from organic acids by means of reacting a carboxylic acid with dialkylcarbonate in an alcohol-containing solvent without any extrinsic acid or base catalyst is described. A benefit of the preparation process is that it can make the separation and extraction of ester products simpler and more facile vis-a-vis conventional isolation techniques.

Alcohol-mediated esterification of carboxylic acids with carbonates

A process for purifying a filtered fermentation broth of succinic acid is described. The process involves separating succinic acid from the other organic acids and salts in a raw filtered broth using a non-functionalized chromatographic resin. The operation can be run either as an isocratic elution to yield free succinic acid, or as a gradient or binary elution to produce succinate salt.

Purification of succinic acid from fermentation broth on non-functionalized chromatographic resin

A method for making the compound of Formula I: is set forth using alkylation, amidation, chlorination and phosphate installation procedures.

Methods of making HIV attachment inhibitor prodrug compound and intermediates

Growing community of inventors

Decatur, IL, United States of America

Mitchell J Schultz