Monsanto Company

Mitchell J Pulwer

William H Miller

Sherrol L Baysdon

Helen L Janoski

David B Reitz

Terry M Balthazor

Van R Gaertner

Donald L Fields, Jr

Described herein is a process for preparation of substituted pyridine dicarboxylate compounds.

Process for preparation of fluoromethyl-substituted pyridine

Ammonium salt of methyl 4,4,4-trifluoro-3-oxobutanethioate (TMTFAA).

Ammonium salt of methyl 4,4,4-trifluoro-3-oxo-butanethioate

A process for dehydrofluorination of a 2,6-(bis) trifluoromethyl-dihydropyridine-3,5-dicarbothioic acid ester.

A process for dehydrofluorination of a 2,6-(bis)trifluoromethyl-dihydropyridine-3,5-dicarbothioic acid ester.

A process for producing an aromatic thiolester by mixing an alkyl or aryl thiol with an alkali metal hydroxide aqueous solution and, in the presence of a phase transfer catalyst, reacting it with an aromatic acid halide. Diacid halides may be used to produce bisthiol esters.

Process for preparation of aromatic thiol esters

Described herein is a process for dehydrohalogenation of substituted dihydropyridine dicarbothioate compounds.

Process for preparation of fluoromethyl-substituted piperidine

Described herein is a process for preparation of substituted piperidine dicarbothioate compounds.

There is disclosed a process for producing the alkali metal salts of N-phosphonomethylglycine which comprises heating to an elevated temperature a di-alkali metal salt of N-alkyl-N-(2-hydroxyethyl)aminomethylphosphonic acid.

Oxidation/dealkylation process

A process for the preparation of an N-substituted aminomethylphosphonic acid comprising reacting a 2,5-diketopiperazine compound with phosphorous acid and formaldehyde in an acidic medium.

Process for the preparation of N-substituted aminomethylphosphonic acids

A process for the preparation of an N-substituted aminomethylphosphonic acid comprising reacting a substituted amine, urea or carbamate substrate compound with phosphorous acid and formaldehyde in an acidic medium.

A process for the preparation of a glyphosate product. An .alpha.-substituted N-phosphonomethylamino diacetic acid substrate is contacted in an aqueous medium with molecular oxygen in the presence of a catalyst for the oxidative cleavage of a substituent from the imino nitrogen of the substrate. Cleavage produces a glyphosate product, carbon dioxide, a higher aldehyde, or ketone. Novel intermediates and methods of preparation thereof are also disclosed.

Process for the preparation of a glyphosate product

There is disclosed a process for the preparation of N-phosphonomethylglycine by dealkylation of N-alkyl-N-phosphonomethylglycine. The N-alkyl moiety contains an electron withdrawing group in the 2-position. Certain novel N-alkyl-N-phosphonomethylglycines are disclosed.

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St. Louis, MO, United States of America

Mitchell J Pulwer