Merck Sharp + Dohme Corp.

Merck Sharp & Dohme LLC

Mitchell H Keylor

Peter H Fuller

Anmol Gulati

Hua Zhou

Barbara A Pio

Solomon D Kattar

Gregori J Morriello

Derun Li

Nunzio Sciammetta

Santhosh Francis Neelamkavil

Jing Su

Yi-Heng Chen

John J Acton, Iii

Min Lu

Vladimir Simov

Xin Yan

Michael J Ardolino

William P Kaplan

Luis Torres

Kaitlyn Marie Logan

Rebecca Elizabeth Johnson

Kaila A Margrey

John J Iii Acton

The present invention is directed to certain 2-aminoquinzaoline derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R, R, and Rare as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

N-linked isoquinoline amides as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof

The present invention is directed to substituted certain 1-pyrazolyl, 5-, 6-disubstituted indazole derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and ring A are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of diseases, such as Parkinson's disease, in which LRRK-2 kinase is involved.

1-pyrazolyl, 5-, 6-disubstituted indazole derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof

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Malden, MA, United States of America

Mitchell H Keylor