Regeneron Pharmaceuticals, Inc.

Columbia University

Mount Sinai School of Medicine

City University of New York

Mitchell Goldfarb

George D Yancopoulos

Samuel H Davis

Thomas H Aldrich

Peter C Maisonpierre

Pamela F Jones

Czeslaw Radziejewski

Joanne Bruno

Ming-Ming Zhou

Xi Zhan

Nicholas W Gale

Dover Katarzyna

Isolated peptides are provided that are effective in inducing long-term inactivation of voltage-gated sodium channels (VGSCs) in mammalian cells. Such peptides are useful in reducing the action potentials of these excitable cells, for example, neurons, myocytes, and tonic muscle cells, in mammals in need thereof.

Isolated A-type FHF N-terminal domain peptides and methods of use

The present invention provides fragments of SNT and FGFR which can form a binding complex that is amenable to structural determinations by NMR spectroscopy. The three-dimensional structural data is also included as part of the invention. In addition, the present invention provides methodology for related structure based rational drug design using the three-dimensional data. Nucleotide and amino acid sequences of the fragments are also provided.

Methods of indentifying modulators of the FGF receptor

Methods of identifying modulators of the FGF receptor

The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.

TIE-2 ligands, methods of making and uses thereof

Method of blocking blood vessel growth using tie-2 ligand 2

The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body, which specifically binds a human TIE-2 ligand. The invention also provides an antibody that specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.

Tie-2 ligands

Antibodies to human TIE-2 ligands

Novel ligands that bind Eph family receptors are identified, and methods for making the soluble ligands in biologically active form are described. cDNA clones encoding these novel proteins enable production of the recombinant proteins, which are useful to support neuronal and other receptor-bearing cell populations.

Method of enhancing the biological activity of Eph family ligands

This invention provides a purified polypeptide having growth factor activity and a defined amino acid sequence. The invention also provides a purified nucleic acid molecule encoding the polypeptide. This invention further provides methods for producing the polypeptide as well as uses thereof. Finally, this invention provides methods for detecting the polypeptide.

Oncogene encoded polypeptide having growth factor activity and methods

Ongogene encoding polypeptide having growth factor activity

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River Edge, NJ, United States of America

Mitchell Goldfarb