Other

Houston Advanced Research Center

Sigma Genosys, L.p.

Mitchell D Eggers

Daniel J Ehrlich

Mark Alexander Hollis

Michael E Hogan

Kenneth Loren Beattie

John Shumaker

The invention provides methods for detecting a labeled sample molecule bound to an immobilized probe by electrochemiluminescence. The method comprises providing a multiplexed molecular analysis system comprising a reaction chamber comprising a reaction substrate comprising a plurality of biosites, each biosite comprising a plurality of similar capture probes attached to the reaction substrate, the reactions substrate comprising an embedded conductive material connected to an electrical source and providing a sample comprising a plurality of molecules labeled with a electrochemiluminescent label; adding a solution comprising this sample to the reaction chamber; applying a voltage from the electrical source to the conductive material after sufficient time has passed for a labeled molecule to bind to a capture probe, thereby inducing an electrochemical event within the electrochemiluminescent label that releases a detectable amount of electromagnetic energy; and, detecting the released electromagnetic energy.

Methods for multiplexed biochemical analysis

A method and apparatus for identifying molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. Each test site includes a probe formed therein to bond with an associated target molecular structure. An electrical signal is applied to the test site and the electrical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.

Multi-site detection apparatus

Multi site molecule detection method

Growing community of inventors

The Woodlands, TX, United States of America

Mitchell D Eggers