Fluidigm Canada Inc.

Eastman Chemical Company

Xerox Corporation

University of Toronto

Other

The Perkin-elmer Corporation

Applied Biosystems, LLC

Winnik, Mitchell A.

Vancaeyzeele, Cedric

Baranov, Vladimir I.

Mitchell Alan Winnik

Vladimir I Baranov

Mark Nitz

Xudong Lou

Allan S Jones

David E Mills

Steven Menchen

Francoise M Winnik

Ben F Johnson

Anthony R Davidson

Cedric Vancaeyzeele

Lei Shen

Robert M Borg

Andrij Pich

Cedric Van-Caeyzeele

Brett Williamson

Luke S Egan

The invention relates to a new type of element encoded particles suitable for the attachment of bio molecules to enable massively multiplex bio-analytical methods, and to calibrate and tune the elemental flow cytometer mass spectrometer (FC-MS).

Particles containing detectable elemental code

Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).

Polymer backbone element tags

Method for the preparation of inorganic-NP-composite microgels is based on the reversible transfer of microgels between water and an organic solvent such as tetrahydrofuran (THF). The method is used to produce semiconductor nanocrystals, often referred to as quantum dots (QDs) which are well known for their unique optical, electrical, magnetic and catalytic properties, as the inorganic NPs, recognizing that the best quality QDs are synthesized by a high temperature process in organic media, and have their surface covered with hydrophobic ligands (such as trioctylphosphine oxide, TOPO) that render the NPs insoluble in an aqueous solution.

Loading quantum dots into thermo-responsive microgels by reversible transfer from organic solvents to water

An electrophoresis separation medium is disclosed comprising a matrix of a copolymer composed of a linear hydrophilic polymer segment having a selected substantially uniform segment length and hydrophobic polymer segments carried on each end. Also disclosed is an electrophoresis method employing the separation medium which permits high resolution separation of polynucleotides, especially in DNA sequencing operations.

Viscous electrophoresis polymer medium and method

A viscous electrophoresis separation medium is disclosed. The medium is formed by a matrix formed by a copolymer composed of hydrophilic polymer segments having selected, substantially uniform segment lengths, and a plurality of hydrophobic polymer segments carried on, and spaced from one another by the hydrophilic polymer segments. Also disclosed is an electrophoresis method which employs the separation medium, and novel copolymers used in forming the medium.

This invention relates to naphthalenedicarboxylic acid containing polymer compositions having reduced fluorescence. More specifically, the polymers contain at least 0.1 mole percent of a dicarboxylic acid selected from 2,6-naphthalenedicarboxylic acid or 2,6-naphthalenedicarboxylate ester, with 0.1 to 5 mole percent of a copolymerizable halogen containing aromatic compound. These polymers are useful for packaging applications where clarity and/or aesthetic appeal are of concern.

Naphthalenedicarboxylic acid containing polymer/halogen compound

This invention relates to naphthalenedicarboxylic acid containing polymer compositions having reduced fluorescence. More specifically, the polymers contain at least 0.1 mole percent of 2,6-naphthalenedicarboxylic acid or 2,6-naphthalenedicarboxylate ester, with 0.1 to 5 mole percent of a copolymerizable aromatic ketone. These polymers are useful for packaging applications where clarity and/or aesthetic appeal are of concern.

Naphthalenedicarboxylic acid containing polymer compositions having

This invention relates to a poly(ethylene 2,6-naphthalene dicarboxylate) composition having reduced fluorescence. More specifically, the composition contains poly(ethylene 2,6-naphthalene dicarboxylate) with 0.1 to 5 mole percent of a copolymerizable halogen containing aromatic compound. The polyesters are useful for packaging applications where clarity and/or aesthetic appeal are of concern.

Poly(ethylene 2,6-naphthalene dicarboxylate)/halogen compound

This invention relates to a poly(ethylene 2,6-naphthalene dicarboxylate) composition having reduced fluorescence. More specifically, the composition contains poly(ethylene 2,6-naphthalene dicarboxylate) with 0.1 to 5 mole percent of a copolymerizable aromatic ketone. The polyesters are useful for packaging applications where clarity and/or aesthetic appeal are of concern.

Poly(ethylene 2,6-naphthalene dicarboxylate)/aromatic ketone

An ink composition comprised of a solution comprised of a dye comprised of a porphyrin chromophore.

Growing community of inventors

Toronto, Canada

Mitchell Alan Winnik