Council of Scientific and Industrial Research

Mitali Ray

Samir Bhattacharya

Santu Bandyopadhyay

Keshab Chandra Roy

Bikash Chandra Pal

Goutam Banerjee

Tanusree Biswas

Chiranjib Pal

Monidipa Gosh

A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract ofby HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination.

Herbal composition for treating CD33+ acute and chronic myeloid leukemia and a method thereof

Described is an in vitro method for developing dendritic Langerhans type cells, for use in immunotherapy against cancer or infectious diseases and enhancement of graft survival in mammals. The method includes the steps of: culturing cells selected from peripheral blood monocytes and bone marrow cells in a medium containing platelets obtained from the same species or phylogenetically close species; and incubating the culture at 30 to 40&#xb0; C. for a period sufficient to enable formation of mature dendritic Langerhans type cells.

In vitro method to generate dendritic Langerhans type cells

A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water: methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract ofby HPLC, with retention time of 3.6 and 24.0 minutes respectively, with said fractions used both individually, and in combination, and a composition comprising the said fraction nos. 1 and 9.

This invention relates to use of betel leaf extract to induce IFN&#x3b3; from human peripheral blood mononuclear cells and as a Thtype immuno modulator, wherein the said method comprises the steps of, preparing water extract of betel leaf, preparation of human peripheral blood mononuclear cells, incubation of hPBMC with betel leaf extract for a period of 18&#x2013;48 hours, extraction of RNA for cytokine specific RT-PCR or for flow cytometry for the detection of intracellular cytokine protein, subjecting RNA for RT-PCR to obtain PCR products using IFN&#x3b3; specific known primers, and enhancement of IFN&#x3b3; as reflected by IFN&#x3b3; specific band.

Use of betel leaf extract to induce IFN-gamma production from human peripheral blood T cells and as a Th1 type immunomodulator

A new herbal-based composition and method for treatment of CD33+ acute and chronic myeloid leukemia byleaf extracts, and to provide a process for the isolation of active fractions from leaves or any other plant parts ofto treat CD33+ AML and CML with a simplified method of isolation of active components from all plant parts ofpossessing biological activities relevant to the treatment of CD33+ AML and CML.

Herbal-based composition for treating acute and chronic myeloid leukemia

A method of treating CD33+ acute and chronic myeloid leukemia in animals including humans, using fraction nos. 1 and 9 obtained from water:methanol fraction by column chromatography, with ratio of water and methanol ranging between 1:5 to 5:1, wherein said water:methanol fraction is obtained from the polar extract ofby HPLC, with retention time of 3.6 and 24.0 minutes respectively, with the fractions used both individually, and in combination, and a composition including the fraction nos. 1 and 9.

This invention relates to method of treating visceral leishmaniasis or kala-azar by administering effective amount of betel leaf extract or lyophilized extract together with or associated with an additive and a composition comprising betel leaf extract with a pharmaceutically acceptable additive.

Anti-leishmanial activity of betel leaf extract

This invention relates to use of betel leaf extract to induce IFN&ggr; from human peripheral blood mononuclear cells and as a Th type immuno modulator, wherein the said method comprises the steps of, preparing water extract of betel leaf, preparation of human peripheral blood mononuclear cells, incubation of hPBMC with betel leaf extract for a period of 18-48 hours, extraction of RNA for cytokine specific RT-PCR or for flow cytometry for the detection of intracellular cytokine protein, subjecting RNA for RT-PCR to obtain PCR products using IFN&ggr; specific known primers, and enhancement of IFN&ggr; as reflected by IFN&ggr; specific band.

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Calcutta, India

Mitali Ray