Illumina Corporation

Illumina Singapore Pte. Ltd.

Illumina Cambridge Limited

Misha Golynskiy

Sergio Peisajovich

Saurabh Nirantar

Seth McDonald

Michael Previte

Molly Min He

Kay Klausing

Hamed Tabatabaei Ghomi

Matthew William Kellinger

BeiBei Wang

Jonathan Mark Boutell

Alexandra Exner

Mariko Matsuura

Ryan Craig

Kyrie Johnson

Eric Murtfeldt

Molly He

Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.

Polymerases, compositions, and methods of use

Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low pre-phasing rates when using ambiently stored polymerases, as well as methods and kits using the same.

A method of characterizing candidate agents including steps of (a) providing a library of candidate agents attached to nucleic acid tags; (b) contacting the library with a solid support to attach the candidate agents to the solid support, whereby an array of candidate agents is formed; (c) contacting the array with a screening agent, wherein one or more candidate agents in the array react with the screening agent; (d) detecting the array to determine that at least one candidate agent in the array reacts with the screening agent; (e) sequencing the nucleic acid tag to determine the tag sequences attached to candidate agents in the array; and (f) identifying the at least one candidate agent in the array that reacts with the screening agent based on the tag sequence that is attached to the at least one candidate agent.

Platform for discovery and analysis of therapeutic agents

Presented herein are methods and compositions for thermostable DNA polymerases that may be used to improve the PCR process and to improve the results obtained when using a thermostable DNA polymerase in other recombinant techniques such as DNA sequencing, nick-translation, and reverse transcription.

Polymerases

Growing community of inventors

San Diego, CA, United States of America

Misha Golynskiy