Takeda Pharmaceutical Company Limited

Takeda Chemical Industries, Inc.

Misayo Sera

Naohiro Fukuda

Tomomi Ikemoto

Isao Aoki

Hiroyuki Tawada

Toshiaki Nagata

Makoto Yamashita

Mari Adachi

Takeshi Yamasaki

Hideya Mizufune

The present invention provides a production method for 5-Aryl-1H-Pyrolle-3-Carbontirile compounds: The productions method provides key intermediates useful for a method of preparing additional pyrrole compounds useful as a pharmaceutical product, particularly an acid secretion inhibitor, a productions method of an intermediate used for this method, a novel intermediate, and the like.

Process for producing 5-aryl-1H-pyrolle-3-carbonitrile compounds by dehalogenation

The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction. 

5-aryl-1H-pyrrole-3-carbonitrile and a pharmaceutical product using the same

Process for producing pyrrole compound

A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: [wherein Rand Rare each hydrogen or an optionally substituted hydrocarbon group; Ris an optionally substituted aromatic group; and C is a benzene ring which may further have a substituent in addition to the amino group]. The process enables industrially advantageous production of intermediates for the synthesis of optically active 2,3-dihydrobenzofuran compounds useful as preventive and/or therapeutic drugs for neurodegenerative diseases and so on.

Process for preparing optically active 2,3-dihydrobenzofuran compounds

A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound:[wherein Rand Rare each hydrogen or an optionally substituted hydrocarbon group; Ris an optionally substituted aromatic group; and C is a benzene ring which may further have a substituent in addition to the amino group]. The process enables industrially advantageous production of intermediates for the synthesis of optically active 2,3-dihydrobenzofuran compounds useful as preventive and/or therapeutic drugs for neurodegenerative diseases and so on.

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Suita, Japan

Misayo Sera