Mitsubishi Chemical Corporation

Misao Okitsu

Norimichi Iwase

Koichi Sugawara

Yoshikuni Tamao

Yasuhiro Morinaka

Masahiro Ohshima

Naoto Inakoshi

Masahiro Oshima

Shigeo Sugiyama

Compounds represented by the general formula (I) wherein n represents 1 or 2; R,represents, for example, a C,-C,alkyl group which may be substituted with a C,-C,cycloalkyl group or carboxyl group; R,represents hydrogen atom, a C,-C,alkyl group or other; and R,represents amino group or amidino group, whose example include trans-4-amino-&lsqb;(S)-N-&lsqb;(S)-2-propoxycarbonylamino-3-isopropylthio-3-methyl-butanoyl&rsqb;prolyl&rsqb;aminomethylcyclohexane. The compounds have potent inhibitory activity against thrombin, and are useful as anticoagulants.

Penicillaminamide derivatives

A prolineamide derivative represented by the formula (I): ##STR1## or a salt or hydrate thereof or a pharmaceutically acceptable salt thereof, which has a protease inhibition activity and is useful as an active ingredient of pharmaceutical compositions is provided.

Prolineamide derivatives

Growing community of inventors

Kanagawa, Japan

Misao Okitsu