Zentiva K.s.

Krka, D.d., Novo Mesto

Miroslav Veverka

Josef Hajicek

Hana Stepankova

Heinrich Brath

Martin Putala

Stefan Vodny

Silvo Zuppancic

Eva Veverkova

The invention provides a process for the preparation of a sartan derivative of formula (I) (formula as filed in paper form) (I) wherein the substituents have the meaning indicated in the description, or a pharmaceutically acceptable salt thereof, comprising reacting 2-cyanophenylboronic acid or a derivative thereof with a p-halobenzyl-1H-imidazole derivative of formula (VI), (formula as filed in paper form) (VI) wherein (part of formula as filed in paper form), X, Y, Rand Rare as defined above, and Z is I, Br or Cl, in the presence of a transition metal catalyst and an inorganic or organic base. The invention also provides new intermediates of formula (V), (formula as filed in paper form) (V) wherein M is an alkali metal or an NRRRRgroup; and of formula (II) (formula as filed in paper form) (II). 

Process for the preparation of sartan derivatives and intermediates useful in such process

A method for manufacturing hydrogen sulphate (alpha S) of the alpha-(2-chlorophenyl)-6,7dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid methyl ester (clopidogrel hydrogen sulphate) of formula I, in crystalline Form I, wherein the compound of formula is separated out of a solution of clopidogrel in the form of the free base or salt in a solvent selected from the series of primary, secondary or tertiary C1-C5 alcohols, their esters with C1-C4 carboxylic acids, or optionally of mixtures thereof. 

Method for manufacturing crystalline form I of clopidogrel hydrogen sulphate

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Miroslav Veverka