Univerzita Palackeho V Olomouci

Ustav Experimentalni Botaniky Av Cr, V.v.i.

Bioapex, S.r.o.

Ustav Experimentalni Botaniky Akademie Ved Ceske Republiky

Institute of Experimental Botany of the Academy of Sciences of the Czech Republic

Centre National De La Recherche Scientifique

Freie Universitat Berlin

Institute of Experimental Botany

Uniwersytet W Bialymstoku

Univerzita Palackeho

Univerzita Palackego V Olomouci

Fakultni Nemocnice Olomouc

Ustau Experimentalni Botaniky Av-cr

&#xda;stav Experiment&#xe1;lni Botaniky Akademie Ved Cesk&#xe9; Republiky

Syngenta Participations Ag

Miroslav Strnad

Karel Dolezal

Marek Zatloukal

Lukas Spichal

Vladimir Krystof

Libor Havlicek

Jiri Voller

Lucie Plihalova

Jiri Gruz

Igor Popa

René Lenobel

Radek Jorda

Ondrej Plihal

Frank J Massino

Lucie Szucova

Stefaan Werbrouck

Marian Hajduch

Borivoj Vojtesek

Antonin Sturc

Jan Holub

Rene Lenobel

Petr Galuszka

Vaclav Mik

Eva Reznickova

Jaroslav Nisler

Jitka Vostalova

Alena Rajnochova Svobodova

Jitka Ulrichova

Alena Kadlecova

Radoslav Koprna

Hana Vylicilova

Laurent Meijer

Peter Martin Fischer

Emile R Bisagni

Tomas Werner

Thomas Schmulling

Michel Legraverend

Lenka Zahajska

Vladimir Divoky

Dana Hradecká

Stjepan Uldrijan

Petr Mlejnek

Kveta Fuksova

Daniela Moravcová

Tereza Radosova Muchova

Jaroslav Vesel&yacute;

Mari&aacute;n Hajd&uacute;ch

Tomas Gucky

Petr Kanovsky

Noemi Bucharova

Vladim&iacute;r Krystof

Gabriel Gonzales

Jan Walla

Jan Hanus

Jana Bibova

Marketa Gemrotova

Magdalena Bryksova

Tomas Pospisil

Stefan Zahler

Angelika Vollmar

Adeyemi Oladapo Aremu

Aloka Kumari

Ponnusamy Baskaran

Johannes Van Staden

Jana Klaskova

Jacek Witold Morzycki

Agnieszka Wojtkielewicz

Jana Oklestkova

Lucie Hoffmannova

Petr Cankar

Iveta Frysova

Martin Hönig

Jan Slouka

Jitka Frebortova

Ludek Frohlich

A para-topolin mesylate salt and its crystalline form is disclosed. Cosmetic and therapeutic applications, and compositions containing this compound, are also disclosed. Mesylate salt of para-topolin has a wide range of biological activities, including antioxidative, anti-inflammatory, anti-senescent and anti-aging while showing low toxicity and excellent solubility.

Mesylate salt of para-topolin, compositions containing said salt and use thereof

Heterocyclic nitrogen-containing purine derivatives and their use in the medicinal applications and compositions containing these derivatives is disclosed. A new generation of compounds possessing selective antineurodegenerative properties on neuronal cells and tissues and that can be particularly used in the treatment and prophylaxis of neurodegenerative disease, particularly in the treatment and prophylaxis of Parkinson's disease is also disclosed.

Heterocyclic nitrogen-containing purine derivatives, pharmaceutical preparations containing these derivatives and their use in neuroprotection

The invention relates to N,N-disubstituted-9-(2-oxacycloalkyl)-9H-purine-2, 6-diamine derivatives and their use as drugs and cosmetics. The compounds of the present invention exhibit a number of biological activities associated with oxidative stress inhibition, especially anti-aging, anti-inflammatory and anti-neurodegenerative biological activities. The invention also relates to cosmetic and pharmaceutical compositions containing such derivatives as active agents.

9-(2-oxacycloalkyl)-9H-purine-2,6-diamine derivatives and their use for the treatment of skin disorders

5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidine derivatives of formula I that are effective inhibitors of kinases and exhibit strong antiproliferative and proapoptotic properties on lymphoma cells. Derivatives in the treatment of blood hyperproliferative diseases, such as Non-Hodgkin lymphomas are also disclosed.

5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidines for treatment of lymphoma

The present invention relates to novel 2,6-disubstituted-9-cyclopentyl-9H-purines of general formula I, capable of inhibiting the activity of kinases such as FLT3, CDKs and PDGFRs in cancer and other related proliferative diseases. The invention further includes pharmaceutical compositions containing the 2,6-disubstituted-9-cyclopentyl-9H-purines. Compounds of the present invention can be used as active ingredients of a pharmaceutical compositions for treating acute myeloid leukemia (AML).

2,6-disubstituted-9-cyclopentyl-9H-purines, use thereof as medicaments, and pharmaceutical compositions

Adenine derivatives substituted at the C2, N6, and N9 purine positions having antisenescent and combined photoprotective UVA/UVB effects. These substances are particularly suitable as anti-senescent and UV-photoprotective component in cosmetic preparations, plant protection preparations and in preparations for the treatment/application of tissue cultures. 

Adenine derivatives and their use as UV-photoprotective agents

The invention relates to substituted 6-anilino-9-heterocyclylpurine derivatives of formula I wherein R denotes one to five substituents independently selected from the group hydrogen, halogen, hydroxy, amino, alkyloxy and alkyl group, R2 is selected from the group comprising amino, halogen, hydroxy, thio, and alkylthio group, Cyc is five- or six-membered heterocyclic ring containing one oxygen atom. The derivatives are useful for inhibition of plant stress.

Substituted 6-anilino-9-heterocyclylpurine derivatives for inhibition of plant stress

6-aryl-9-glycosidpurines of general formula I and pharmaceutically acceptable salts thereof with alkali metals, ammonia, amines, or addition salts with acids, wherein

6-aryl-9-glycosylpurines and use thereof

6-aryl-9-glycosidpurines of general formula I and pharmaceutically acceptable salts thereof with alkali metals, ammonia, amines, or addition salts with acids, whereinGly represents &#x3b2;-D-arabinofuranosyl or &#x3b2;-D-2'-deoxyribofuranosyl,Ar represents benzyl or furfuryl, each of which can be unsubstituted or substituted by one or more, preferably one to three, substituents selected from the group comprising hydroxyl, alkyl, halogen, alkoxy, amino, mercapto, carboxyl, cyano, amido, sulfo, sulfamido, acyl, acylamino, acyloxy, alkylamino, dialkylamino, alkylmercapto, trifluoromethyl, trifluoromethoxy, for use as antisenescent and UV protective compounds in animals.

6,8-Disubstituted-9-(heterocyclyl)purines for use in pharmaceutical and cosmetic compositions and applications are provided. These 6,8-disubstituted-9-(heterocyclyl)purines have a wide range of biological activities, including for example antioxidant, anti-inflammatory, anti-senescent, anti-aging, as well as well as other activities which are especially useful in pharmaceutical and cosmetic applications. Compositions may include additional excipients and auxiliary substances. Methods of treatment of animals, mammals, plants, cells, yeast, and cells in tissue culture are also disclosed.

6,8-disubstituted-9-(heterocyclyl)purines, compositions containing these derivatives and their use in cosmetic and medicinal applications

Substituted 1,2,3-thiadiazol-5yl-urea derivatives, their use as anti-senescence and anti-stress factors of plant cells, organs and the whole plant, and preparations containing these derivatives.

1,2,3-thiadiazol-5yl-urea derivatives, use thereof for regulating plant senescence and preparations containing these derivatives

5-substituted-7-[4-(2-pyridyl)phenylmethylamino]-3-isopropylpyrazolo[4,3-d]pyrimidines are potent inhibitors of protein kinases, especially cyclin-dependent kinases such as CDK2 and CDK5, and display antileukemic, pro-apoptotic, antiangiogenic and anticancer activities. The invention also relates to processes for their preparation, to pharmaceutical compositions and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation, apoptosis, angiogenesis and inflammation, such as leukemia and metastatic solid cancer.

5-substituted 7- [4-(2-pyridyl)phenylmethylamino] -3-isopropylpyrazolo4,3-D]pyrimidine derivatives, use thereof as medicaments, and pharmaceutical compositions

The invention relates to 6-substituted 9-halogenalkyl purine derivatives of the general formula I wherein R6 is selected from the group comprising &#x2014;NH-furfuryl, &#x2014;NH-(4-hydroxy-3-methylbut-2-en-1-yl), &#x2014;NH-(3-methylbut-2-en-1-yl), &#x2014;NH-(4-hydroxy-3-methylbutyl), &#x2014;NH-(4-hydroxy-1,3-dimethylbut-2-en-1-yl), &#x2014;NH-(4-hydroxy-1,3-dimethylbutyl), &#x2014;NH-benzyl, &#x2014;NH-phenyl, wherein benzyl, furfuryl and phenyl can be unsubstituted or optionally substituted with 1 to 3 substituents selected from the group comprising hydroxy, halogen, methyl and methoxy, and R9 is selected from the group comprising C-Calkyl or C-Calkenyl wherein each of the groups is substituted with one or more halogen atoms, for use in the regulation of growth and development of plant cells, organs and/or whole plants. The invention also relates to preparations containing these derivatives and to novel to 6-substituted 9-halogenalkyl purines.

Use of 6-substituted 9-halogenalkyl purines for regulation of growth and development of whole plants, plant cells and plant organs; novel 6-substituted 9-halogenalkyl purines

The invention relates to substitution derivatives of N-benzyladenosine-5'-monophosphate of the general formula I, wherein (R)represents 1 to 4 substituents (n is in the range 1-4), which can be the same or different, and R is selected from the group comprising Cto Calkyl, Cto Calkoxy, amino, halogen, hydroxy, mercapto and nitro groups, and the pharmaceutically acceptable salts thereof. This invention also relates to methods of their preparation, their use as medicaments and in other biotechnological applications, and a therapeutic composition containing these derivatives.

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The invention relates to new substituted 6-(2-aminobenzylamino)purines, represented by the general formula I, which can be used in CDK inhibition, in particular, in the treatment of viral infections and diseases involving cell proliferation. The invention further includes pharmaceutical preparations containing substituted 6-(2-aminobenzylamino)purines.

Substituted 6-(2-aminobenzylamino)purine derivatives, their use as medicaments and preparations containing these compounds

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Olomouc, Czechia

Miroslav Strnad