Wisconsin Alumni Research Foundation

State of Oregon

Miroslav Malkovsky

Milton Yatvin

Michael H Stowell

Daniel H Rich

Yvonne M Angell

Andrew D Wells

The present invention provides methods for specifically increasing expression of MHC class I molecules in cells, and in particular, in poorly immunogenic tumor cells as well as in pathogen-infected cells. Also provided by the present invention are methods for increasing presentation of endogenous antigens onto the cell surface by MHC class I molecules, as well as methods of increasing the immunity of an animal against an antigen. The methods presented herein are useful in enhancing immune recognition of any cell infected with any pathogen, for in vitro and in vivo screening of candidate immunogene therapeutic approaches, and for enhancing the generation of antibodies to an otherwise poorly immunogenic antigen or cell. The present invention further provides methods for reducing or increasing the radiation sensitivity of a cell.

Immune response enhancer

Compositions and methods are described for the synthesis of novel analogs of cyclosporin A, and the use of those analogs as immunostimulatory agents.

Immunostimulatory agents

This invention relates to methods of facilitating the entry of peptides into cells and targeting such peptides to specific organelles within the cell. The invention provides methods for delivering and specific targeting of antigenically-active peptides to cells for the specific production of immunological reactivity against such peptides, as well as compositions and pharmaceutical compositions of matter comprising such peptides. This invention thereby provides improved methods for vaccine production and in vivo vaccination against pathogenic microorganisms. Methods for alleviating autoimmune disease and ameliorating tissue and organ transplant rejection using such conjugates are also provided.

Growing community of inventors

Madison, WI, United States of America

Miroslav Malkovsky