Bristol-myers Squibb Compnay

Smithkline Beecham Corporation

Miriam K Franchini

Vijay H Naringrekar

Joseph B Bogardus

Francis Y F Lee

Gopadi M Venkatesh

Krishnaswamy Srinivas Raghavan

Thomas A Haby

Ubrani V Venkataram

Pharmaceutical compositions containing C-21 modified epothilone derivatives, methods for their preparation and dosing regimen for administration of these epothilone compounds are provided. The compositions are stable and readily prepared for administration by dissolution in aqueous vehicles suitable for intravenous administration. A process for formulating C-21 modified epothilone derivatives for oral and parenteral administration is disclosed.

Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives

This invention relates to carvedilol methanesulfonate, compositions containing this compound and methods of using carvedilol methanesulfonate to treat hypertension, congestive heart failure and angina.

Carvedilol methanesulfonate

Stable solutions of rebeccamycin analog consist essentially of (a) water, (b) 8-N-(diethylaminoethyl)rebeccamycin in an effective dosage amount, and (c) pharmaceutically acceptable acid such that the presence of a molar equivalence thereof would solubilize (b), said acid being present in excess of said molar equivalence to provide a stabilizing pH ranging from 3 to 4, preferably from 3.0 to 3.6. A preferred solution contains 10 mg/ml of the free base and tartaric acid in equimolar amount with the free base to provide a pH of 3.5. Preferably, the solution is prepared by forming a suspension of 8-N-(diethylaminoethyl)rebeccamycin in water and adding acid to provide a pH ranging from 3 to 4.

Stable solutions of rebeccamycin analog

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Allentown, NJ, United States of America

Miriam K Franchini