New York University

Max Planck Gesellschaft Forgerung Der Wissenschaften

Max Planck Gessellschaft

Miriam Fuchs

Axel Ullrich

Joseph Schlessinger

Jan M Sap

Wolfgang Vogel

A novel receptor-type protein tyrosine phosphatase-&#x3ba; (RPTP&#x3ba;) protein or glycoprotein and the DNA coding therefor is expressed in a wide variety of mammalian tissues. The RPTP&#x3ba; protein or glycoprotein may be produced by recombinant means. Antibodies to the protein, methods for measuring the quantity of the protein, methods for screening compounds, such as drugs, which can bind to the protein and inhibit or stimulate their enzymatic activity, are provided. Further, methods for inhibiting homophilic binding of Type II RPTP, especially RPTP&#x3ba; molecules are provided.

Receptor-type phosphotyrosine phosphatase-kappa antibodies

A novel receptor-type protein tyrosine phosphatase-.kappa. (RPTP.kappa.) protein or glycoprotein and the DNA coding therefor is expressed in a wide variety of mammalian tissues. The RPTP.kappa. protein or glycoprotein may be produced by recombinant means. Antibodies to the protein, methods for measuring the quantity of the protein, methods for screening compounds, such as drugs, which can bind to the protein and inhibit or stimulate their enzymatic activity, are provided. Further, methods for inhibiting homophilic binding of Type II RPTP, especially RPTP.kappa. molecules are provided.

Nucleic acid encoding novel receptor-type phosphotyrosine

Receptor-type phosphotyrosine phosphatase-.kappa.

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Starnberg, Germany

Miriam Fuchs