Albert Einstein College of Medicine

The University of North Carolina at Chapel Hill

Miriam Braunstein

William R Jacobs, Jr

Steven A Porcelli

William R Jacobs

Volker Briken

William R Jacob

Provided are recombinanthaving a mutation in an nlaA gene or in a nuoG gene. Also provided are isolated and purified nlaA proteins and nuoG proteins from a. Additionally provided are isolated and purified nucleic acids comprising a recombinant nlaA gene or a recombinant nuoG gene. Further provided are methods of inducing an immune response in a mammal and methods of making a recombinantusing the nlaA gene or the nuoG gene.

Mycobacterial mutants affecting host apoptosis

Provided are mycobacteria comprising (a) a mutation that is not in a SecA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that eliminates SecA2 activity. Also provided are mycobacteria that comprise a mutation in a SecA2 gene that eliminates SecA2 activity, where the mycobacteria are notor. Additionally provided are methods of inducing an immune response in a mammal and methods of inducing an immune response to a pathogenicin a human using the above mycobacterial mutants.

Mycobacterial SecA2 mutants

Growing community of inventors

Chapel Hill, NC, United States of America

Miriam Braunstein