Duke University

Yale University

Sentilus Holdco, LLC

Miriam Amiram

Ashutosh Chilkoti

Farren J Isaacs

Felipe Garcia Quiroz

Adrian Haimovich

Angus Hucknall

Dieter Söll

Dieter Soil

Srinath Rangarajan

Compositions, systems, and methods for preparation of polypeptides having multiple iterations of non-standard amino acids are provided. The compositions and method can be used to produce recombinant proteins at a greater yield than the same or similar polypeptides made using conventional compositions, systems, and methods. Accordingly, in some embodiments, the polypeptides are ones that could not be made using conventional methods and reagents, or could not be made a sufficient yield or purity to serve a practical purpose using conventional methods and reagents. Polypeptides made using the disclosed compositions, systems, and methods are also provided.

Compositions and methods of use thereof for making polypeptides with many instances of nonstandard amino acids

Disclosed herein are methods of detecting a target RNA, methods of diagnosing an individual with a disease or condition when a target RNA associated with the disease or condition is detected, and methods of conveying via a communication medium data from the detection of a target RNA.

Direct detection of RNA by surface initiated enzymatic polymerization

The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. The polypeptides may be used to deliver therapeutics to a biological site and to develop bioactive polypeptides that are environmentally responsive.

Phase transition biopolymers and methods of use

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Stamford, CT, United States of America

Miriam Amiram