Biomerieux, Inc.

Universite Paul Sabatier

Biomerieux Sa

Université Paul Sabatier (toulouse Iii)

Mireille Sebbag

Guy Serre

Michel C Jolivet

Christian Vincent

Colette Jolivet-Reynaud

Pascal T Dalbon

Michel Simon

Michel Arnaud

Odile Letourneur

Maria Leonor Nogueira

Brigitte Incaurgarat

Elisabeth Girbal-Neuhauser

Cyril Clavel

Maria Léonor Nogueira

The invention relates to citrulline peptides with anti-inflammatory properties. The invention also relates to an in vitro model for activation of macrophages, induced by immune complexes between specified IgG of rheumatoid arthritis and their citrulline targets.

Peptides modulating the activity of macrophages, useable for the treatment of rheumatoid arthritis

The invention relates to novel citrulline peptides derived from fibrin &#x3b1; and &#x3b2; chains which are recognizable by specific citrulline antiprotein autoantibodies (AAPC) of a rheumatoid arthritis (PR) and to the use thereof for detecting the presence of said specific PR AAPC in a biological sample.

Citrulline peptides derived from fibrin and recognized by rheumatoid arthritis specific autoantibodies, and the use thereof

A method for detecting anti-filaggrin-autoantibodies specific to rheumatoid arthritis in a biological sample, by providing a filaggrin with no citrulline residues (FNC) having an arginine residue or a filaggrin peptide with no citrulline residues (PFNC) having an arginine residue. Also provided are a citrulline-containing filaggrin (FC) having the peptide sequence of the FNC where some arginine residues have been converted to citrulline residues or a citrulline-containing peptide (PFC) having the peptide sequence of the PFNC, where at least one arginine residue has been converted to a citrulline residue. The sample is contacted with the FNC or PFNC and the FC or PFC, and the resulting immune complexes are detected and quantified, with a value Xand X, respectively. Anti-filaggrin-autoantibodies specific to rheumatoid arthritis are determined to be present in the biological sample if the value of Xis greater than the value of X.

Method for detecting rheumatoid arthritis-specific autoantibodies

The invention concerns citrulline polypeptide derived from fibrin useful for diagnosing or treating rheumatoid arthritis.

Fibrin citrulline derivatives and their use for diagnosing or treating rheumatoid arthritis

The invention concerns an artificial antigen specifically identified by the anti-filaggrin autoantibodies present in the serum of patients suffering from rheumatoid polyarthritis, and consisting of one polypeptide comprising all or part of the sequence of one filaggrin unit or of a related molecule, in which an arginine radical has been substituted by a citrulline radical. The invention also concerns the use of this antigen for diagnosing rheumatoid polyarthritis.

Antigens derived from filaggrin and their use for diagnosing rheumatoid polyarthritis

Growing community of inventors

Toulouse, France

Mireille Sebbag