Institut De Recherche Pour Le Developpement (ird)

Institut De Recherche Pour Le Developpement

Mireille Cavaleyra

Jean-Loup Lemesre

Denis Sereno

Philippe Holzmuller

The invention relates to nucleic acid constructions, characterized in that they comprise nucleic acids which are isolated in the sense position and which are capable of coding for an immunogenic protein of promastigotes or amastigotes of, said nucleic acids responding to one of the sequences SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, SEQ ID No. 4, SEQ ID No. 5 et SEQ ID No. 11 and coding for a protein respectively exhibiting a sequence SEQ ID No. 6, SEQ ID No. 7, SEQ ID No. 8, SEQ ID No. 9, SEQ ID No. 10 et SEQ ID No. 12. The invention can be used for over-expression of the genes ofcoding for an excretion/secretion antigen.

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Montpellier, France

Mireille Cavaleyra