Corning Incorporated

Mircea Despa

Eric John Mozdy

Joydeep Lahiri

Po Ki Yuen

Kenneth Richard Miller

Stephen Joseph Caracci

David M Root

Richard Curwood Peterson

Brian L Webb

Keith A Horn

Stephen Charles Currie

Jinlin Peng

Paul Martin Elliott

Michael Donavon Brady

Mark D Salik

Dale Russell Hess

James B Stamatoff

Christine Marie Share

A die for forming an extrusion includes a die body, a body feed section and an extrusion forming section. The die body may include an inlet and an outlet defining an extrudate flow path through the die body. The body feed section may be positioned between the inlet and outlet and includes an arrangement of body feed channels. The extrusion forming section may be positioned between the body feed section and the outlet and includes a thin-wall forming portion fluidly coupled to at least one thick-wall forming portion. The thin-wall forming portion may include an array of pins extending from the body feed section towards the outlet and the thick-wall forming portion may include at least one baffle section positioned in the extrudate flow path through the thick-wall forming portion. The area of the thick-wall forming portion may be greater than an interstitial area between the pins.

Dies for forming extrusions with thick and thin walls

Methods for making extrusion dies using a LIGA process, a German acronym for lithography (Lithographie), electroplating (Galvanoformung), and molding (Abformung), are described. The resulting extrusion dies can be used, for example, for extrusion of cellular ceramic substrates, precision extrusion of optical fiber or optical fiber precursors, or other applications where profile extrusion requires high dimensional precision and/or has otherwise intricate patterns.

Methods of making extrusion dies

A device and methods for performing biological or chemical analysis is provided. The device includes an array of three-dimensional microcolumns projecting away from a support plate. Each microcolumn has a relatively planar, first surface remote from the support plate. An array of multiple, different biological materials may be attached to the first surface. The device, when used in combination with existent micro-titer well plates, can improve efficiency of binding assays using microarrays for high-throughput capacity.

Microcolumn-platform based array for high-throughput analysis

A grating-coupled waveguide (GCW) and a method are described herein that can be used to detect the presence of a biological substance (e.g., cell, drug, chemical compound) in a sensing region of the GCW. The GCW includes a substrate, a diffraction grating and a waveguide film that has a higher index of refraction than the substrate which has an index of refraction&#x2266;1.5. The relatively low-index substrate effectively increases the sensitivity of the GCW by causing the waveguide mode to shift towards a biological substance located in a sensing region above the waveguide film, thereby increasing the field strength of the mode's evanescent tail in this region. In one embodiment, an array of the GCWs are incorporated within the wells of a microplate.

Substrate index modification for increasing the sensitivity of grating-coupled waveguides

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Mircea Despa