Rani Therapeutics, LLC

Alva Therapeutics, Inc.

Leland Stanford Junior University

Incube Labs, LLC

Intrapace, Inc.

Spinal Modulation, Inc.

Entrack, Inc.

Mir A Imran

Arturo S Rosqueta

Deepak R Gandhi

Ted W Layman

Radhika Korupolu

Mir Hashim

Olivier K Colliou

Albert G Burdulis, Jr

Ronald Jay Berenson

Joel M Harris

Timothy J Hughes

Eyad Kishawi

Sharon L Lake

Richard W O'Connor

Mercedes Morales

Elaine To

Jeffery M Kramer

Timothy H Williams

Chang Jin Ong

Baber R Syed

Paul Spehr

Emily Arnsdorf

Fred I Linker

Brian J Mossop

Peter Herrmann

Greg Method

Talat Imran

Lu Wang

Kyle Horlen

Ben Tranchina

Nicholas C DeBEER

Huma Arastu

Rekha Vaidyanathan

Kamran Behzadian

Andrew Mangogna

Delia Anna Gratta

Arthur Hsu Chen Chang

Matthew Harrison

Baber Syed

Daniel H Kim

Richard W O'connor

Glen Mclaughlin

Sanjay Patel

Timothy Williams

Phillip Morgan

Paul Spher

Richard W O'CONNOR

Harm Tenhoff

Embodiments of the invention provide apparatus and methods for stimulating L cells in the intestinal tract to produce incretins for the treatment of conditions including diabetes and obesity. Many embodiments provide a method and apparatus for the treatment of diabetes by electrically stimulating L-cells to secrete incretins to stimulate or otherwise modulate the production of insulin. Particular embodiments provide a swallowable capsule for stimulating L-cells in the intestinal tract as the capsule moves through the tract. The capsule can include two or more electrodes for providing electrical stimulation to L-cells, a power source for powering one or more components of the capsule, a sensor for sensing the location of the capsule in the intestinal tract; a controller and a waveform generator for generating the electrical signals emitted by the electrodes to stimulate the L-cells to secrete incretins such as GLP-1 to stimulate insulin production for glucose regulation of diabetic conditions.

Swallowable capsule and method for stimulating incretin production within the intestinal tract

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

Preparation comprising exanatide for delivery into a lumen of the intestinal tract

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Los Altos Hills, CA, United States of America

Mir A Imran