University of Washington

Fred Hutchinson Cancer Center

Fred Hutchinson Cancer Research Foundation

Miqin Zhang

Narayan Bhattarai

Omid Veiseh

Mandana Veiseh

Forrest M Kievit

Richard Glen Ellenbogen

Chen Fang

Jonathan Whitney Gunn

Nathan Kohler

Zhensheng Li

James M Olson

Frederick A Matsen

Raymond W Sze

Dennis Edmondson

Ashleigh Cooper

Guanyou Lin

Qingxin Mu

Richard Revia

S-Bahram Bahrami

Patrik Gabikian

Stephen Florczyk

Matthew Chi-hang Leung

Hui Wang

John R Silber

Zachary Stephen

Multifunctional nanoparticle for targeted therapeutic drug delivery, comprising (a) an iron oxide core having silica-polyethylene glycol coupled thereto to provide an iron oxide coated core, (b) a cytotoxic agent reversibly associated with the coated core; (c) an immunomodulating agent reversibly associate with the coated core; and (d) a tumor targeting agent associated with the coated core. Methods for using the nanoparticle to treat cancers and methods for making the nanoparticle.

Iron oxide nanoparticle for targeted chemo-immunotherapy

Polyarginine-coated nanoparticle, and methods for making and using the nanoparticle. The nanoparticle can have a core that includes a material that imparts magnetic resonance imaging activity to the particle and, optionally, include one or more of an associated therapeutic agent, targeting agent, and diagnostic agent.

Polyarginine-coated magnetic nanovector and methods of use thereof

Boron-doped graphene quantum dots, methods for making the boron-doped graphene quantum dots, and methods for magnetic resonance imaging using the boron-doped graphene quantum dots.

Paramagnetic boron-doped graphene quantum dots and their application for safe magnetic resonance imaging

Guided cell patterning arrays for single cell patterning are disclosed. The arrays include a plurality of cell adhesion sites that are individually isolated on an inert surface. Each cell adhesion site has one or more cell adhesion peptides having affinity to a cell surface receptor. The inert surface is resistant to cell adhesion.

Arrays and methods for guided cell patterning

Nanoparticle having a crosslinked chitosan-polyethylene oxide oligomer copolymer coating to which O-benzylguanine is covalently coupled, compositions that include the nanoparticle, and methods for using the nanoparticle to treat brain cancers.

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Nanoparticle having a poly(beta-amino ester) coating. The poly(beta-amino ester) coating includes one or more therapeutic agents that can be delivered by the particle and one or more anchoring groups that couple the polymer to the nanoparticle's core surface. In certain embodiments, the poly(beta-amino ester) includes one or more polyalkylene oxide groups. The poly(beta-amino ester) can further include a targeting agent to target the nanoparticle to a site of interest and a diagnostic agent that allows for imaging of the particle. Methods for making and using the nanoparticles are also provided.

Theranostic nanoparticle and methods for making and using the nanoparticle

A centrifugal electrospinning apparatus, centrifugal electrospinning method for the production of fibrous structures, and electrospun fibrous structures are provided.

Centrifugal electrospinning apparatus and methods and fibrous structures produced therefrom

A hollow fibrous conduit for promoting regeneration of a severed nerve, comprising a first end for coapting the conduit to a first end of a severed nerve and second end for coapting the conduit to a second end of the severed nerve, the hollow fibrous conduit comprising chitosan-poly(caprolactone) fibers. Methods for making the conduit and methods for using the conduit for nerve regeneration.

Nanofibrous conduits for nerve regeneration

Methods for culturing cancer cells in vitro using a three-dimensional scaffold, scaffolds that include the cultured cancer cells, and methods for using the cultured cancer cells and the scaffolds that include the cultured cancer cells in anticancer therapeutic drug development.

Chitosan-alginate scaffold cell culture system and related methods

A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate.

Fluorescent chlorotoxin conjugate and method for intra-operative visualization of cancer

The present invention provides compositions comprising an interpolymer of chitosan and polyethylene glycol, wherein the interpolymer is a liquid below 25&#xb0; C. and a gel above 35&#xb0; C. The present invention also provides methods for using the compositions to deliver drugs to a living body over time.

Biodegradable chitosan-PEG compositions and methods of use

The present invention provides porous structures that each comprise chitosan, alginate and divalent metal cations, wherein: (a) the chitosan is ionically linked to the alginate; and (b) the structure is porous and has a compressive yield strength of at least 0.35 MPa. The present invention also provides methods for making the porous structures, and methods for using the porous structures as substrates to grow living cells.

Porous structures and methods of use

Alginate nanofibers, scaffolds that include alginate nanofibers, implantable devices that include alginate nanofibers, and methods for making the alginate nanofibers by electrospinning.

Growing community of inventors

Bothell, WA, United States of America

Miqin Zhang