Cosmed Pharmaceutical Co., Ltd.

Osaka University

Public University Corporation Nara Medical University

Mio Saito

Fumio Kamiyama

Ying-shu Quan

Shinsaku Nakagawa

Shouta Kitaoka

Ying-Zhe Li

Hirofumi Yamashita

Hideo Asada

Naoki Okada

Sachiko Hirobe

Ying-Shu Quan

To provide a composition of a coating liquid for microneedle which is optimal for coating a microneedle with a medicinal ingredient. The coating liquid for microneedle of the present invention is an aqueous solution containing, as essential components of a base, a water-soluble polysaccharide, a monosaccharide and/or a disaccharide and a surfactant, characterized in that a ratio of the water-soluble polysaccharide to the base is 2 to 60 mass %, and the hardness after being dried is 10 N or more. The coating liquid for microneedle may further contain a water-soluble polyalcohol, and preferably a monosaccharide and/or a disaccharide is 30 to 95 mass %, a surfactant is 0.05 to 5 mass %, and a water-soluble polyalcohol is 10 mass % or less in the base. As the water-soluble polysaccharide, hydroxypropyl cellulose, hyaluronic acid, or carboxymethyl cellulose is preferable.

Coating liquid for microneedles, microneedle-coating substance, and microneedle array

Provided are a microneedle with excellent performance and a method for manufacturing the microneedle. A microneedle array in which a polyglycolic acid is used as a material, crystallinity of the polyglycolic acid is 21% or more and axial contraction rate of tips is 99% or more, and a manufacturing method in which a polyglycolic acid are injection-molded at a cylinder temperature of 230-280&#xb0; C., a metal mold temperature of 60-130&#xb0; C., and an injection pressure of 1000-1500 KPa so as to manufacture a microneedle array in which crystallinity of the polyglycolic acid is 21% or more and an axial contraction rate of tips is 99% or more.

Microneedle and method for producing same

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Kyoto, Japan

Mio Saito