Shanghai Institute of Pharmaceutical Industry

China State Institute of Pharmaceutical Industry

Js Innopharm (shanhai) Ltd.

Shanghai Modern Pharmaceutical Co., Ltd.

Js Innopharm Ltd.

Minyu Liu

Quanhai Liu

Xuejun Wu

Xiaoling Huang

Yifang Deng

Ying Liu

Zhen Zhang

Li Cai

Renhai Chen

Lin Xiao

Haiyan Sun

Chungang Li

Wei Wu

Guoping Wang

Jintao Zhang

Jinyao Chen

Guobin Ren

Yan Qin

Jian Hou

Zhiru Xu

Shuai Zhao

Lin Yao

Zhenpeng Yu

Shenrong Tang

Gouping Wang

Pengxia Yu

Liling Jin

Xiangduan Tan

Tian Zhang

Mianli Pan

Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R, R, R, R, R, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.

Amide compound, preparation method and uses thereof

Disclosed herein is a method of treating psoriasis involving the use of compound of formula I and/or a pharmaceutically acceptable salt thereof. 

Heterocyclic compounds for treating psoriasis

An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.

Amorphous asiatic tromethamine salt and preparation method thereof

The invention discloses a dithiolopyrrolone compound represented by formula I or its pharmaceutically acceptable salts, wherein X, R, R, R, Rare defined as in the description. The invention also discloses the preparation of such compounds, and the use of such compounds in preparation of medicaments for increasing peripheral white blood cells and in preparation of ancillary medicaments for inhibiting the decrease of peripheral white blood cells in radiotherapy or chemotherapy.

Dithiolopyrrolone compounds, the preparation and the use thereof

Growing community of inventors

Shanghai, China

Minyu Liu