Alteogen, Inc.

Minsoo Byun

Soon Jae Park

Hye-Shin Chung

Sunbae Lee

Ji-Sun Kim

Jin Hwan Kim

Hyung-Nam Song

Jeong Soo Cho

Sang Hoon Yun

Kyuwan Kim

Ji Hyeon Yeon

Ki Seok Nam

Kibum Park

Disclosed is a method for producing hyaluronidase or a variant thereof. Specifically, the method is capable of changing the N-glycan levels under culture conditions including a controlled concentration of glucose in the culture medium and a decreased culture temperature for a specific culture time period, thereby increasing the specific activity by 10% or more and improving the quality and production yield.

Method for producing recombinant hyaluronidase

The present disclosure relates to an antibody-drug conjugate in which a modified antibody comprising a motif having a specific structure at the end of the antibody is conjugated to a drug via a linker, and a composition comprising the same, and more particularly to a modified antibody-drug conjugate (mADC) comprising a modified antibody that has a significantly increased conjugation yield of drug due to a motif bound to the heavy chain or light chain C-terminus of the antibody, and to a composition comprising the same.

Antibody-drug conjugate comprising modified antibody

The present invention relates to a composition for stabilizing TNF&#x3b1;-binding protein exhibiting physiological activity, and more specifically, to a composition for stabilizing protein including basic amino acid and sugar and/or ammonium salt, a pharmaceutical formulation including the same, and a method for stabilizing TNF&#x3b1;-binding protein. The formulation including basic amino acid; and sugar and/or ammonium salt according to the present invention effectively inhibits aggregation, denaturation and oxidation of TNF&#x3b1;-binding protein used for treating various diseases, for example, an anti-TNF-alpha antibody, such that the protein is capable of being preserved and stored for a long time, which is widely usable and effective in a medical field using TNF&#x3b1;-binding protein, for example, an anti-TNF-alpha antibody.

Composition for stabilizing protein and pharmaceutical formulation comprising the same

Growing community of inventors

Daejeon, South Korea

Minsoo Byun