Takeda Chemical Industries, Inc.

Matsushita Electric Industrial Co., Ltd.

Mizuno Corporation of America

Minoru Yamada

Junji Oshima

Yasuaki Ogawa

Yasutaka Igari

Ichiro Sasaki

Tatsuo Fujii

Shigehisa Taketomi

Shigeru Kamei

Kazuhiro Kume

Robin Smith

Yasuyuki Kajita

Seiko Ishiguro

Robert J Ball

Robert J Ready

John E Schulte

Koji Fujii

Goro Shimaoka

Shizuo Togo

Nobuyuki Haji

Kazuhiko Ishii

Takao Teraoka

Nobuyuki Nakagawa

Yasumichi Muto

Toshiro Heya

Keiiti Mizutani

Akira Ogino

Hisanobu Funahashi

Hisanobu Fugahashi

Hideki Tsuruoka

Yoshiya Shiraishi

Hideki Tsuroka

A semiconductor laser heating apparatus has a measuring instrument for measuring an optical-power output relative to a current to be supplied to the semiconductor laser. The heating apparatus also has a calculator for calculating a correction coefficient of the optical-power output based on the measured data, and has a controller for correcting a supply current to the semiconductor laser relative to a value determined by an optical-power output determiner based on the calculation result. The heating apparatus employing optical fibers as an output terminal thus can always produce a desirable heating condition regardless of the optical-power output deteriorated with the lapse of time.

Semiconductor laser heating apparatus

A transmucosal therapeutic composition comprising a physiologically active peptide or protein and a cytidine nucleotide derivative was produced. The above composition results in a satisfactory transmucosal absorption of physiologically active peptides or proteins which are otherwise hardly absorbed from the mucosa. Since it allows self-administration to the mucosa, such as the nasal, vaginal or digestive tract mucosa, in lieu of injection which causes pain, the invention is of great utility as a pharmaceutical dosage form for physiologically active peptides or proteins which must be administered over a protracted time.

Transmucosal therapeutic composition

A method of producing sustained-release microcapsules containing a biologically active substance from an W/O emulsion comprising an inner aqueous phase containing said biologically active substance and an external oil phase containing a biodegradable polymer, characterized in that microcapsules formed on microencapsulation of said biologically active substance with said biodegradable polymer are heated at a temperature not lower than the glass transition temperature of said biodegradable polymer but not so high as to cause aggregation of the microcapsules. This method enables the production of very useful sustained release microcapsules adapted to release a bologically active substance at a calculated rate over a protracted time period starting immediately following administration without an initial burst within one day following administration.

Method of producing sustained-release microcapsules

(1) A composition which comprises erythropoietin and hyaluronic acid shows a sustained-release of the medicine in a living body, and (2) A water-soluble composition which comprises (a) a pharmacologically active polypeptide secreted by an animal body or its derivative or a chemically synthesized pharmacologically active substance, (b) a water-soluble species' of hyaluronic acid or its nontoxic salt and (c) a water-soluble protein injectable into body fluids without showing any substantial pharmacological activity brings about a prolonged action in vivo of a pharmacologically active substance. In addition, the composition can be administered using a small-gauge needle and thereby contributes to relieving pain in patients.

Water-soluble composition for sustained-release

Baseball glove

The invention provides a method of purifying biodegradable aliphatic polyesters which comprises dissolving, in a readily water-soluble organic solvent, a biodegradable aliphatic polyester which contains low-molecular substances and adding water to the resulting solution to thereby remove said low-molecular substances, biodegradable aliphatic polyesters obtained by said method and containing low-molecular substances with a molecular weight of 1,000 or less in an amount of not higher than 3%, and drug-containing compositions which comprise any of said biodegradable polyesters.

Biodegradable high-molecular polymers, production and use thereof

A transmucosal therapeutic composition comprising a physiologically active peptide or protein and a cytidine nucleotide derivative is described. The above composition results in a satisfactory transmucosal absorption of physiologically active peptides or proteins which are otherwise hardly absorbed from the mucosa. Since it allows self-administration to the mucosa, such as the nasal, vaginal or digestive tract mucosa, in lieu of injection which causes pain, the invention is of great utility as a pharmaceutical dosage form for physiologically active peptides or proteins which must be administered over a protracted time.

The present invention relates to a baseball glove having means located on a bottom palm portion for enhancing glove flexibility. The baseball glove includes a thumb stall, at least one finger stall, and a hand receiving opening. The glove includes a notch formed in a lower portion of the glove, and at least one slit formed in a web portion such that the notch and slits increase flexibility of the glove and facilitate opening and closing of the glove.

Baseball glove having enhanced flexibility

(1) A composition which comprises erythropoietin and hyaluronic acid shows a sustained-release of the medicine in a living body, and (2) A water-soluble composition which comprises (a) a pharmacologically active polypeptide secreted by an animal body or its derivative or a chemically synthesized pharmacologically active substance, (b) a water-soluble species of hyaluronic acid or its nontoxic salt and (c) a water-soluble protein injectable into body fluids without showing any substantial pharmacological activity brings about a prolonged action in vivo of a pharmacologically active substance. In addition, the composition can be administered using a small-gauge needle and thereby contributes ot relieving pain in patients.

Water-soluble composition for sustained-release containing epo and

A water soluble composition is described which comprises (a) a water soluble pharmacologically active peptide selected from the group consisting of cytokines or haematopoietic factors and (b) a sulfate group-containing acidic mucopolysaccharide and/or a desulfated modification of a naturally occurring sulfate group containing acidic mucopolysaccharide, and which brings about prolonged action of pharmacologically active peptides in a living body.

A light-beam heating apparatus utilizes light energy effectively by having a light emitting portion of a radiating lamp coincide with a first focal point of an ellipsoidal reflecting mirror automatically and with high accuracy Light intensity and positional information at a light receiving end of an optical fiber are detected by means of a photodetector, a light intensity signal converted by a photoelectric converter is inputted to an arithmetic drive circuit, a drive mechanism of a radiating lamp fitting mechanism is actuated, the light emitting portion of the radiating lamp is moved in the X-axis direction, the Y-axis direction and the Z-axis direction successively in a direction that the light intensity increases, a central axis of a distribution of light condensed by an ellipsoidal reflecting mirror and a central part of the light receiving end of the optical fiber are made to always coincide with each other so as to utilize the light energy effectively. The light energy incident to the optical fiber is computed from a light intensity signal and a detected position, and a lamp current is controlled so as to make the error with respect to an indicated value of a command circuit smaller, thereby to stabilize the light radiation energy at a predetermined value.

Light-beam heating apparatus

The invention thus provides a core-shell polymer comprising a core phase which is rubbery polymer and a shell phase which is a glassy polymer with an unsaturated dicarboxylic acid or its mono-alkyl ester as a constituent thereof, wherein the toluene-soluble fraction of the core-shell polymer accounts for not more than 10% by weight. It also provides polyamide resin compositions comprising said core-shell polymer and molded articles produced by molding said compositions. The resin compositions and molded articles which comprises the core-shell polymer as an impact modifier have good features, especially a high impact strength at temperature ranging from room temperature to -30.degree. C.

Core-shell polymer, resin composition and molded article thereof

A polymer for a prolonged release preparation which comprises

Prolonged release preparation and polymers thereof

This invention relates to a core-shell polymer which is useful for polyoxymethylene resin, a polyoxymethylene resin composition containing the core-shell polymer and a molded article made of the polyoxymethylene resin composition. The core-shell polymer comprises a rubbery polymer core and a glassy polymer shell and has substanially no detectable anion. This core-shell polymer makes the molded articles be improved on the impact strength, elongation at the weld line, etc. The molded articles is used as various products (such as gears, reels, etc.).

Growing community of inventors

Kawanishi, Japan

Minoru Yamada