Ss Pharmaceutical Co., Ltd.

Ssp Co. Ltd

Minoru Tokizawa

Takemitsu Asaoka

Masaru Matsumoto

Susumu Sato

Hiromichi Eto

Kazunori Maebashi

Sunao Takeda

Yasushi Kaneko

Kazuya Ishida

Hideaki Matsuda

Tatsuhiko Katori

Tadayuki Kuraishi

Yoshihiko Kanamaru

Naokata Taido

Fumio Ishii

Koichi Tachibana

Kazuhiko Irinoda

Ryuichi Kawahara

Kenichi Kukita

Seiji Ishizeki

Koji Kusano

Tadayoshi Taniyama

Tatsuhiko Kateri

Mari Otsuka

Imidazole derivatives of the formula (1) or salts thereof, pharmaceuticals containing the derivatives or the salts, and intermediates for the synthesis of the derivatives or the salts (wherein R is lower alkyl; R is alkyl or aralkyl; and X is halogeno). These compounds exhibit G-CSF-like activities and can be substituted for G-CSF preparations.

Imidazole derivatives or their salts

Azole derivatives or salts thereof

Described is a triazole derivative represented by the formula (1):

Triazole derivative or salt thereof, preparation process thereof and pharmaceutical containing said compound as an effective ingredient

Triazole derivative or slat thereof, preparation process thereof and pharmaceutical containing said compound as an effective ingredient

Described is a triazole derivative represented by the formula (1): ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient. The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.

Triazole derivative or salt thereof, preparation process thereof and

A compound having formula (2): ##STR1## wherein R represents hydrogen, a straight or branched C.sub.1-10 alkyl group, a C.sub.7-11 aralkyl group or a C.sub.2-10 carboacyl group and m stands for 1 to 5.

Triazole derivative or salt thereof

Described is a triazole derivative represented by the formula (1): wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an aralkyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a halogenoalkyl and n stands for an integer of 0 to 2, or salt thereof; a preparation process of said compound and a pharmaceutical comprising said compound as an effective ingredient. The compound as described above has high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.

Triazole derivative or salt thereof preparation process thereof, and

Described is a triazole derivative represented by the formula (1): ##STR1## wherein R.sup.1 represents a lower alkyl group or an aralkyl group, R.sup.2 represents a hydrogen atom, a lower alkyl group, an aralkyl group or an acyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a trifluoromethyl group, n stands for an integer of 0 to 2 and m stands for an integer of 1 to 5, or salt thereof; and also a pharmaceutical comprising the derivative or salt thereof as an effective ingredient. The compound as described above has a high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.

Described is a triazole derivative represented by the formula (1) or salt thereof, preparation process thereof, preparation intermediates represented by the formulas (2) and (3), and a pharmaceutical comprising the compound represented by the formula (1) or salt thereof. ##STR1## wherein n stands for 0, 1 or 2, X.sup.1 represents H or F and Y.sup.1 and Y.sup.2 each independently represents H, halogen or CF.sub.3.

Triazole derivative, preparation process thereof and pharmaceutical

Described is a triazole derivative represented by the formula (1) or salt thereof, preparation process thereof, preparation intermediates represented by the formulas (2) and (3), and a pharmaceutical comprising the compound represented by the formula (1) or salt thereof. wherein n stands for 0, 1 or 2, X.sup.1 represents H or F and Y.sup.1 and Y.sup.2 each independently represents H, halogen or CF.sub.3.

Triazole derivative and pharmaceutical comprising the same as an

Described is a triazole derivative represented by the formula (1): wherein R represents a hydrogen atom, an alkyl group, an aralkyl group or an acyl group, n stands for 0 to 2 and m stands for 1 to 5 or salt thereof, and a pharmaceutical containing the derivative or salt as an effective ingredient.

Novel imidazole derivatives and their acid adducts are disclosed. The imidazole derivatives are represented by formula: ##STR1## wherein R.sub.1 represents an alkyl group, R.sub.2 represents a hydrogen atom, an alkyl group which may have a substituent, or an aralkyl group which may have a substituent, provided that R.sub.1 and R.sub.2 are not both methyl groups at the same time. They have strong antimicrobial activity, especially against those fungi belonging to the genera Candida, Trichophyton, Microsporum, and Epidermorphyton, as well as against Gram-positive bacteria, and thus is useful as a antimicrobial agent.

Growing community of inventors

Narita, Japan

Minoru Tokizawa