Chugai Seiyaku Kabushiki Kaisha

Wisconsin Alumni Research Foundation

Minoru Shindo

Isao Matsunaga

Nobuhiro Oi

Teizo Shinozaki

Yusuke Harada

Haruki Ogawa

Hiroshi Okazaki

Takao Noto

Bunya Aoki

Takao Kimura

Hisao Endo

Kanji Moro

Toshiyuki Nebashi

Kiyoshige Ochi

Sakae Takaku

Shigeyuki Kataoka

Chikara Kaneko

Shun-ichi Hata

Hiroyuki Nagano

Koji Mizuno

Takashi Matsuno

Yugo Ikeda

Kouji Furuno

Takeaki Hirano

Takashi Mori

Yasushi Murakami

Tamotsu Yamazaki

Yasuhiro Ohba

Shun-Ichi Hata

Toshichika Ogasawara

Kiyoshige Wakabayashi

Kazushige Sakai

Yoshiyuki Ohsugi

Yasuho Nishii

Shigeru Takanashi

Yasuo Fujimura

Yasuyuki Shiraki

Hector Floyd Deluca

Masayuki Ishikawa

Yoshimitsu Iida

Kazuo Igusa

Masuo Koizumi

Masamitsu Honda

Katsuhito Miyamoto

Yasuhisa Takeda

Masayoshi Ono

Morio Kakimoto

Shin-ichi Kaiho

Sadao Tanaka

Mitsuru Tanemura

Akira Okazaki

Hiroki Mitsui

Toshio Kuroki

Masahiko Matsumoto

Tanaka Sadao

Toshiaki Nakano

Akio Yoshida

Yumiko Tsuruma

Fujimura Yasuo

Tatsuo Kujirai

Matsunaga Isao

Kana Kojima

Akiko Ariga

Tsuneo Iwasaki

Shigeru Sugano

A treating agent whose effective ingredient is an anthranyl derivative of the formula: ##STR1## (wherein R.sub.1 and R.sub.2 may be the same or different and represent a hydrogen atom, a hydroxyl group, a lower alkoxy group, preferably C.sub.1 -C.sub.3 alkoxy group, a lower alkyl group, preferably C.sub.1 -C.sub.3 alkyl group, a nitro group or a halogen atom) is disclosed.

Pharmaceutical composition for treating transplanted tumor cells

Novel uracil derivatives of the formula ##STR1## (wherein R.sub.1, R.sub.2 R.sub.3 and X are defined in the description) and their pharmaceutically acceptable salts, process for preparing the same and pharmaceutical composition containing the same are disclosed. The uracil derivatives have good antitumor activity and, therefore, are useful as antitumor preparation.

Novel uracil derivatives, process for preparing the same and a

Pyrazoloindazole derivatives of the formula: ##STR1## [wherein R.sub.1 is a cyano group, carboxy group, a lower alkoxycarbonyl group or a group ##STR2## (wherein R.sub.2 and R.sub.3 are each a hydrogen atom, a lower alkyl group, a phenyl group which may have a substituent or when taken together with a nitrogen atom, form a heterocyclic ring); X.sup..crclbar. is a counter ion], a process for preparing the same and a pharamaceutical composition containing the same are disclosed. The compounds of the formula above have bronchodilating action and are useful as a medicine.

Pyrazoloindazole derivatives and pharmaceutical composition containing

Novel pyrazoloindazole derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxyl group or benzyloxyl group; R.sub.2 is a hydrogen atom, a halogen atom, a lower alkyl group or phenyl group (provided R.sub.1 and R.sub.2 are not hydrogen at the same time); and X.sup..crclbar. is a halide ion, a hydroxide ion, a methanesulfonate ion, a p-toluene sulfonate ion, a sulfate ion, a nitrate ion, a carbonate ion, an acetate ion, a benzoate ion or a salicylate ion, a process for preparing the derivatives, and a pharmaceutical composition containing the same are disclosed. The derivatives have good bronchodilating action for human without exhibiting substantially bad effects on the functioning of heart, and therefore, they are useful as a drug.

Pyrazoloindazole derivatives and bronchodilating composition

.alpha.-Substituted ureido-benzylpenicillanic acids of the formula ##STR1## (wherein R.sup.1, X and Y are as defined in the description) and pharmaceutically acceptable salts thereof, and a bactericidal composition comprising the above penicillanic acid or the salt and a pharmaceutically acceptable carrier are disclosed. The acids and salts thereof have high antibacterial activities against Gram-positive and Gram-negative bacteria, particularly those of the genus Pseudomonas.

.alpha.-Substituted ureido-benzylpenicillanic acids

Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1 R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.

Cephalosporin derivatives

Cephalosporin derivatives which have an excellent antibacterial action particularly against bacteria belonging to genus Pseudomonas or Serratia and are represented by the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are as defined in the specification, and salts thereof; a process for preparing the same; and an antibacterial preparation containing the same as an active ingredient are disclosed.

Penicillanic acid derivatives which have an excellent antibacterial action particularly against bacteria belonging to family Pseudomonas aeruginosa and are represented by the formula ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 and n are as defined above, and salts thereof; and a process for preparing the same are disclosed.

Penicillanic acid derivatives

Steroid derivatives represented by the formula ##STR1## wherein R.sup.1 and R.sup.2 are as defined hereunder which is useful for easily producing a wide variety of active vitamin D, and a process for preparing the same are disclosed.

Steroid derivatives and process for preparing the same

A terephthalic acid monoamide derivative of the formula: ##STR1## (wherein R is a straight- or branched-chain lower alkyl group; R' and R' may be the same or different, and represent a hydrogen atom, or a straight- or branched-chain lower alkyl group) or pharmaceutically acceptable salts thereof are disclosed. A process for preparing such terephthalic acid monoamide derivative or its salts, as well as an anti-allergic agent containing such derivative or its salts as an effective ingredient are also disclosed.

Terephthalic acid monoamide derivatives, process for preparing the same,

A compound of the formula ##STR1## is useful for treating circulatory diseases.

Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use

3.alpha.,6.alpha.-Dihydroxy-5.beta.-cholestan-24-one or its derivative represented by the formula ##STR1## wherein R is as defined hereunder which is a useful intermediate for the production of an active vitamin D, and a process for preparing the compound of the formula are disclosed.

3.alpha.,6.alpha.-Dihydroxy-5.beta.-cholestan-24-one derivatives and

A steroid derivative represented by the formula ##STR1## wherein R is as defined hereunder and a process for preparing the same are disclosed. The derivative is an intermediate for the production of various useful compounds.

Growing community of inventors

Tokyo, Japan

Minoru Shindo