Kyowa Hakko Kogyo Co., Ltd.

Minoru Sakurai

Toshihide Nakanishi

Toshihiko Hirao

Tomoki Azuma

Kiyoji Hattori

Mamoru Kohata

Production of L-lysine is carried out by a process which involves culturing a mutant microorganism having increased L-lysine productivity belonging to the genus Corynebacterium or Brevibacterium and having a resistance to at least one of purine analog and pyrimidine analog.

Process for producing L-lysine by fermentation

A process is disclosed for producing L-lysine by culturing a microorganism obtained by protoplast fusion and having an ability to produce L-lysine in a nutrient medium, forming and accumulating L-lysine in the resulting culture liquor, and recovering the L-lysine therefrom. Also, there are disclosed a number of microorganisms for producing L-lysine which are obtained by protoplast fusion.

L-glutamic acid is produced by culturing a mutant microorganism belonging to the genus Corynebacterium or Brevibacterium which mutant is temperature-sensitive remediable with an unsaturated higher fatty acid. L-glutamic acid is recovered from the culture liquor.

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Hofu, Japan

Minoru Sakurai