Yamanouchi Pharmaceutical Company Ltd.

Other

Astellas Pharma Gmbh

Ludwig Institute for Cancer Research Limited

Imperial Cancer Research Technology, Ltd.

Suzuhiro U.s.a., Inc.

Tokyo Rope Manufacturing Co., Ltd.

Kyokuto Kogen Concrete Shinko Co., Ltd.

Minoru Okada

Masahiko Hayakawa

Hiroyuki Kaizawa

Hiroyuki Moritomo

Mitsuaki Ohta

Koyo Matsuda

Mayumi Yamano

Ken-Ichi Kawaguchi

Tomonobu Koizumi

Tadao Kojima

Eiji Kawaminami

Yasuo Isomura

Isao Ohata

Noboru Sato

Shunji Kageyama

Isao Kinoyama

Akira Toyoshima

Masaaki Hirano

Toichi Takenaka

Yukiyasu Murakami

Masakazu Imamura

Toru Yoden

Kazuharu Tamazawa

Hideki Arima

Masafumi Kudou

Nobuaki Taniguchi

Kiyoshi Takanobu

Norio Seki

Takashi Furutani

Kenichi Kawaguchi

Akira Matsuhisa

Ryutaro Wakayama

Toshiyuki Kusayama

Takenori Kimura

Noriko Ishikawa

Yoshiaki Shimada

Koji Watanabe

Takashi Kamikubo

Tsukasa Ishihara

Teisuke Suzuki

Frank S Kawana

Yoji Miyazaki

Yanke Zhao

Takayuki Okeno

Masahiro Takeuchi

Takahito Nakahara

Kiyohiro Samizu

Eisuke Nozawa

Hiroshi Koutoku

An anchoring device secures tendons formed of a filament body made of fiber reinforced plastic by inserting a male member into a female member to sandwich the tendons between them. Each of the female member and the male member is formed in a tapered shape inclined from one end toward the other end and the female member and the male member include a plurality of mount portions at predetermined intervals in a circumferential direction of an inclined tapered face between the female member and the male member, each of the plurality of tendons being placed on a different one of the mount portions. The length from the one end to the other end of each of the female member and the male member corresponding to a length direction of the tapered face in contact with the tendon is equal to or larger than 130 mm.

Anchoring device for filament body made of fiber reinforced plastic

The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.

Fused heteroaryl derivatives

The present invention relates to a novel N-phenyl-(2R,5S)dimethylpiperazine derivatives useful as antiandrogenic agent which exhibits a sufficient prostate gland reducing effect as compared with conventional compounds and are excellent in oral activity. The compound of the present application is useful in preventing or treating prostate cancer, benign prostatic hyperplasia, and the like. The present invention also provides a novel intermediate useful in producing the compound of the present invention.

N-phenyl-(2R,5S)dimethylpiperazine derivative

Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione derivative having a GnRH antagonistic effect.

Propane-1, 3-dione derivative

N-phenyl-(2R,5S) dimethylpiperazine derivative

Propane-1,3-dione derivative

Fused imidazolium derivatives

This application relates to a piperazino-substituted novel cyanophenyl derivative in which a substituted carbamoyl or substituted sulfamoyl group having an aryl, heterocyclic or the like group that may have a substituent group is bonded to one nitrogen atom on the piperazine ring. The compound of this application has an anti-androgen action and is useful in preventing or treating prostatic cancer, benign prostatic hyperplasia and the like diseases.

Cyanophenyl derivative

The present invention relates to novel compounds having a phosphatidylinositol 3 kinase (PI3K) inhibiting activity which are useful as medicaments, more particularly as antitumor agent. Novel 3-(imidazo&lsqb;1,2-a&rsqb;pyridin-3-yl) derivatives or salts thereof exhibit an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity, and are thus useful as medicaments, especially as PI3K inhibitors and antitumor agents.

Imidazopyridine derivatives

Growing community of inventors

Tsukuba, Japan

Minoru Okada