Banyu Pharmaceutical Co. Ltd

Minoru Moriya

Akio Kanatani

Takehiro Fukami

Norikazu Otake

Yoshio Ogino

Kenji Matsuda

Hisashi Iwaasa

Yoshikazu Nagae

Takao Suzuki

Shunji Sakuraba

Toshihiro Sakamoto

Akane Ishihara

Hidekazu Takahashi

Hiroyuki Kishino

Makoto Ishikawa

Makoto Jitsuoka

Sayaka Mizutani

Minoru Kameda

The present invention relates to compounds of Formula (I) wherein A, B and C are independently methine, said methine being optionally substituted; D is nitrogen; T, U, V and W are independently methine or nitrogen, said methine being optionally substituted and least two of T, U, V and W are said methine groups; X is &#x2014;N(SOR)&#x2014;, N(COR)&#x2014; or &#x2014;CO&#x2014;; Y is C(R)(R)&#x2014;, &#x2014;O&#x2014; or &#x2014;N(R) and a pharmaceutically acceptable salt, ester or N-oxide derivative thereof.

Benzimidazole derivatives

The invention provides melanin-concentrating hormone receptor antagonists containing as the active ingredient piperidine derivatives represented by the general formula [I]: 

Melanin-concentrating hormone receptor antagonists containing piperidine derivatives as the active ingredient

The present invention relates to a compound of the formula (I): (wherein A,,and D are independently nitrogen or optionally substituted methine; E is nitrogen, methine or hydroxy substituted methine; n is 0 or 1; T, U, V and W are independently nitrogen or optionally substituted methine; X is &#x2014;N(SOR)&#x2014;, &#x2014;N(COR)&#x2014; or &#x2014;CO&#x2014;; Y is &#x2014;C(R)(R)&#x2014;, &#x2014;O&#x2014; or &#x2014;N(R)&#x2014;, provided that the compound (I) when E is nitrogen, n is 0, X is &#x2014;CO&#x2014;, and Y is &#x2014;O&#x2014; is excluded) and the like, which are useful as an agent for the treatment of various diseases related to NPY.

The present invention provides an imidazopyridine compound represented by formula (I), wherein Rand Reach independently represent a Calkyl group et al; Rand Reach independently represent a hydrogen atom, a methyl et al; Aris a divalent substituent representing a monocyclic or bicyclic, 3- to 8-membered aromatic or aliphatic heterocyclic group et al; Arrepresents an aromatic carbocyclic group, or an aromatic heterocyclic group; W represents &#x2014;(CH)et al, and m indicates an integer of from 0 to 10. This compound acts as a melanin concentrating hormone receptor antagonist, and is useful as treating agents for obesity.

Imidazopyridine compound

This invention relates to a benzimidazole derivative of the general formula [I] [wherein B, B, and Brepresent hydrogen atom or lower alkyl; Rand Rare same or different and represent lower alkyl, etc.; Rand Rrepresent hydrogen atom, etc.; W represents a 3 to 8-membered aromatic or alphatic heterocycle, etc.; and Ar represents a substituted or unsubstituted aromatic heterocycle, etc.] This compound functions as an antagonist to melanin-concentrating hormone receptor and is useful as a drug for central diseases, circulatory diseases and metabolic diseases.

Antagonists to melanin-concentrating hormone receptor comprising benzimidazole derivative as active ingredient

A compound represented by the formula [I]: [wherein Rand Rare the same or different and each represents Calkyl, Ccycloalkyl, et al; R, R, and Rare the same or different and each represents hydrogen, Calkyl, et al; X represents &#x2014;N&#x2014;, &#x2014;CH&#x2014;, et al; Yrepresents a single bond, Calkylene, et al; Yrepresents Calkylene, oxy(Calkylene), et al; Arrepresents a monocyclic aromatic carbocyclic group, monocyclic aromatic heterocyclic group, et al; and Arrepresents a 5- or 6-membered aromatic carbocyclic group, aromatic heterocyclic group, et al]. This compound functions as a melanin-concentrating hormone receptor antagonist and is useful as, e.g., a therapeutic agent for obesity, et al.

2-arylcarboxamide-nitrogenous heterocycle compound

The invention provides imidazopyridine derivatives represented by the general formula [I] [in which Rand Rmay be the same or different and stand for Calkyl or the like, Rand Rstand for hydrogen atom, methyl group or the like, W stands for mono- or bi-cyclic 3- to 8-membered aromatic or aliphatic heterocycle or the like, and Ar stands for optionally substituted aromatic heterocycle or the like]. These compounds act as melanin-concentrating hormone receptor antagonist and are useful as medicines for central nervous system disorders, cardiovascular system disorders and metabolic disorders.

Imidazopyridine derivatives

This invention provides 2-aminoquinoline derivatives represented by a general formula [I] 

2-aminoquinoline derivatives

The present invention relates to novel benzimidazole derivatives which are useful as neuropeptide Y receptor antagonists.

Growing community of inventors

Tsukuba, Japan

Minoru Moriya