Otsuka Pharmaceutical Company, Limited

Otsuka Chemical Co., Ltd.

Minoru Kashimoto

Yusuke Kato

Takashi Hayashi

Satoshi Shimizu

Tadashi Mukai

Takahiro Tomoyasu

Yuso Tomohira

Takao Taki

Kazuaki Kakehi

Yasuo Koga

Hiroaki Asai

Fumitaka Goto

Yoko Sakamoto

Naohiro Hayashi

Junji Takaba

Yoshikazu Oka

Daisuke Kuribayashi

Wakako Hirano

Hajime Toguchi

Tetsuroh Ichiba

Masakazu Nagasawa

Masaru Nishida

Kazunari Izumi

Atsushi Azuma

Satoru Nakazato

A low-molecular-weight polysulfated hyaluronic acid derivative useful for treatment of an allergic disease. An agent for treatment of an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, represented by the following general formula (IA) or (IB); wherein n represents a number of 0 to 15; R's each independently represent a hydrogen atom or an SOH group etc.

Low-molecular polysulfated hyaluronic acid derivative and medicine containing same

Disclosed is a method for stabilizing a solid pharmaceutical preparation containing a pharmacological substance and sodium lauryl sulfate, the method comprising incorporating into the preparation at least one member selected from the group consisting of neutral salts, basic salts and basic substances. The preparation containing sodium lauryl sulfate prepared by the method of the invention has superior performance, including high storage stability, suppression of discoloration and deterioration, and prevention of change in its properties, such as the dissolution rate of pharmacological substance from the preparation.

Method for stabilizing preparation

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Osaka, Japan

Minoru Kashimoto