Shionogi Company Limited

Riken Corporation

Shiga University of Medical Science

Minoru Ikeda

Takashi Ono

Kohji Hanasaki

Tomoyuki Ogawa

Tatsuya Takahashi

Kaoru Seno

Tohru Tani

Yoshihiro Kawamura

Atsunori Kashiwagi

Hiroshi Maegawa

Shiro Maeda

Masatomo Rokushima

Minoru Suzuki

Disclosed are: a method for detecting (diagnosing) visceral obesity in a subject; a test agent useful for the method; a method for searching for a substance that can be used as an active ingredient for ameliorating visceral obesity; and an ameliorating agent for visceral obesity or a medicinal agent for preventing a metabolic disease developed as a result of the progression of visceral obesity. As the test agent, a polynucleotide which comprises at least 15 nucleotides and can hybridize with a nucleotide sequence for coiled-coil domain containing protein 3 (CCDC3) gene or a nucleotide sequence complementary to the nucleotide sequence under stringent conditions or an antibody capable of recognizing CCDC3 protein is used.

Test agent for visceral obesity and use thereof

A compound represented by the general formula:wherein Ris &#x2014;CHCOOH and the like; Ris &#x2014;COCONHand the like; Ris C4&#x2013;C6 alkyl; and the like; Ris &#x2014;CH&#x2014;Rwherein Ris aryl and the like; Ris hydrogen or C1&#x2013;C6 alkyl and the like; an optical active compound, a prodrug thereof, or a pharmaceutically acceptable salt, or a solvate having type X sPLAinhibitory effect was found.

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It is provided that type-X sPLAinhibitors are useful in preventing or treating hepatocirrhosis.

Remedies for cirrhosis

Growing community of inventors

Osaka, Japan

Minoru Ikeda